Targeting Toll-like Receptors 7, 8, and 9 Inhibition in Systemic Lupus Erythematosus: Therapeutic Advance and Future Directions
文献类型：期刊论文
| 作者 | Song, Xue1; Asgari, Motahareh1; Lin, Guo-Qiang1; Liu, Hong2,3; Cheng, Jie-Fei4; Nian, Yong3; Feng, Chen-Guo1 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2026-02-17 |
| 页码 | 30 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.5c02765 |
| 英文摘要 | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, characterized by aberrant immune activation leading to widespread inflammation and organ damage. Accumulating studies underscore the pivotal roles of Toll-like receptors 7, 8, and 9 (TLR7/8/9) in SLE development through recognizing nucleic acid ligands and initiating downstream proinflammatory cascades related to the pathogenesis of SLE. In parallel, advances in medicinal chemistry have led to the discovery of monoclonal antibodies and selective small-molecule antagonists. This review uniquely summarizes significant progress in structural biology, structure-activity relationship (SAR) studies-driven antagonist optimization, and the clinical translation of TLR7/8/9 antagonists for SLE therapy, with a particular focus on chemical scaffolds, structure-based drug design, and clinical translation strategies, providing a valuable roadmap for the future design of novel antagonists for SLE. |
| WOS关键词 | PLACEBO-CONTROLLED TRIAL ; CPG-DNA ; AUTOANTIBODY PRODUCTION ; TLR7/8 ANTAGONIST ; DENDRITIC CELLS ; NUCLEIC-ACIDS ; MURINE MODEL ; IFN-ALPHA ; DISEASE ; TLR9 |
| 资助项目 | Shanghai Frontiers Science Center for TCM Chemical Biology[NA] ; National Natural Science Foundation of China[22271195] ; Shanghai University of Traditional Chinese Medicine[2023YZZ01] ; National Key Research and Development Program of China[2023YFC2308200] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001693055400001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/323035]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Cheng, Jie-Fei; Nian, Yong; Feng, Chen-Guo |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Res Ctr Chiral Drug, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Pharm, Sch Chinese Mat, Nanjing 210023, Peoples R China 4.Otsuka Shanghai Res Inst, Shanghai 201321, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Xue,Asgari, Motahareh,Lin, Guo-Qiang,et al. Targeting Toll-like Receptors 7, 8, and 9 Inhibition in Systemic Lupus Erythematosus: Therapeutic Advance and Future Directions[J]. JOURNAL OF MEDICINAL CHEMISTRY,2026:30. |
| APA | Song, Xue.,Asgari, Motahareh.,Lin, Guo-Qiang.,Liu, Hong.,Cheng, Jie-Fei.,...&Feng, Chen-Guo.(2026).Targeting Toll-like Receptors 7, 8, and 9 Inhibition in Systemic Lupus Erythematosus: Therapeutic Advance and Future Directions.JOURNAL OF MEDICINAL CHEMISTRY,30. |
| MLA | Song, Xue,et al."Targeting Toll-like Receptors 7, 8, and 9 Inhibition in Systemic Lupus Erythematosus: Therapeutic Advance and Future Directions".JOURNAL OF MEDICINAL CHEMISTRY (2026):30. |
入库方式： OAI收割
来源：上海药物研究所
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