M & eacute;lange complexes and continental marginal deposits along suture zones can provide crucial insights into the subduction-accretion processes of oceanic lithosphere and continent-continent collisions. Herein, moderately to well-preserved Late Jurassic-Early Cretaceous and late Paleocene radiolarian assemblages, including 86 species within 52 genera, were identified in the Jiangmuna m & eacute;lange and the adjacent Tethyan Himalayan sedimentary strata along the western YarlungTsangpo suture zone, southern Tibet. Reconstruction of the ocean plate stratigraphy revealed that the Jiangmuna m & eacute;lange represents the products of fragmentation and mixing of Early Jurassic-Late Cretaceous ocean plate materials originally accumulated in different portions of the central Neo-Tethyan domain. The bottom-up lithological transition and the southward-younger seamount system indicate that the Neo-Tethyan oceanic lithosphere was subducted northward beneath the Zhongba microterrane, and then the Jiangmuna m & eacute;lange was accreted one unit after another along the southern margin of the Zhongba microterrane during the Late Cretaceous. The adjacent Tethyan Himalayan sedimentary strata were originally deposited in a continental slope-basin environment along the northern margin of the Indian plate since the Middle Jurassic. The occurrence of Selandian-Thanetian radiolarian assemblages implies that deep-water sedimentation persisted along the northern margin of the Indian plate until at least the late Paleocene. Our findings, combined with previously published data, indicate that the Neo-Tethys Ocean existed at least from the Early Jurassic to late Paleocene, and the NeoTethyan late-stage evolution involved at least two subduction-accretion systems along the southern margins of the Lhasa block and the Zhongba microterrane, respectively, prior to the two-stage India-Eurasia collision.