The link between icehouse climates and Oceanic Anoxic Events (OAEs) is highly complex, with controversy over how global icehouse conditions influence regional OAEs. Here, we reconstruct variation of redox conditions using detailed analysis of size distributions and morphologies of framboidal pyrites collected from six sections spanning the uppermost Devonian through Middle Permian in the Baoshan Block, which is a part of the Cimmerian Continent that originated from Gondwana during the Late Paleozoic. Our research shows that the redox conditions in the Baoshan Block during the Early Carboniferous can be compared with those in various regions worldwide, whereas its biotic composition, including biodiversity and abundance, is primarily correlated with those of Eurasia. The redox condition during the middle and late Tournaisian was dominated by stable dysoxia. In contrast, the redox conditions during the Visean became a highly unstable, with frequent anoxic and euxinic events when pulses of the ice age began or expanded. Similarly, the Sakmarian, which is the peak of the Ice Age, experienced frequent anoxic/euxinic events, likely caused by glacio-eustatic sea-level fluctuations and intensified upwelling. The characteristic brachiopod-bryozoan-crinoid assemblages and low-diversity of biota appear linked to the anoxic/euxinic conditions during this age. Following the end of the glaciation during late Kungurian-Wordian, the Baoshan block once again experienced predominantly stable dysoxia that coincided with relatively abundant fauna. This study suggests that both global warming and cooling can trigger anoxic events via distinct pathways, thereby resulting in a spatially heterogeneous redox landscape on a global scale. The redox conditions of upper slope to platform settings, as exemplified by the Baoshan Block, show sensitivity to such environmental changes.