The Late Paleozoic Ice Age (LPIA) represents one of the most profound climatic events in Earth's history, yet the timing of its termination remains contentious. Here, we present integrated biostratigraphical, sedimentological, and carbonate carbon isotope (delta C-13(carb)) data from the Kongshan section in South China to demonstrate a major deglaciation event during the Artinskian, which potentially marked the demise of the LPIA. The Asselian-early Artinskian Chuanshan Formation consists of carbonate cyclothems dominated by alternations between subtidal facies and peritidal-subaerial exposure facies, recording high-frequency sea-level oscillations during an overall lowstand regime. In contrast, the basal Chihsia Formation, broadly correlative with the middle-late Artinskian, is typified by restricted middle-ramp facies with poorly developed cyclothems, reflecting a rapid and large-magnitude transgression. The overlying Kungurian succession consists of monotonous bioclastic wackestone to packstone with no discernible cyclothems, representing a deep outer-ramp setting and a persistent highstand sea level. Carbonate carbon isotope data generally mirror these sea-level changes. Hence, lithofacies and delta C-13(carb) values consistently demonstrate high-frequency sea-level changes through the Asselian to early Artinskian, followed by a great transgression during the middle-late Artinskian. A total of nineteen high-frequency transgression-regression cycles are identified in the Asselian-Sakmarian interval, with an average cycle duration of similar to 0.463 Myr, generally corresponding to the long-eccentricity component of Milankovitch cycles. These Asselian-early Artinskian high-frequency sea-level changes, together with the subsequent middle-late Artinskian transgression, are extensively recognized across South China, North America, and Europe, supporting a glacioeustatic origin. We interpret the Asselian-early Artinskian sea-level oscillations as sedimentary responses to the LPIA acme, and the middle-late Artinskian transgression as a major deglaciation event marking the onset of the transition to a greenhouse climate state.