The large bivalved arthropods Isoxys and Tuzoia were widely distributed in Cambrian marine environments, occupying important evolutionary and ecological positions in early arthropod history. Here, we systematically studied middle Cambrian Isoxys and Tuzoia from four Burgess Shale-type Lagerstatten localities in the Mantou (Wuliuan) and Zhangxia (Drumian) formations of Shandong Province, North China. This study describes I. shandongensis Wang and Huang in Wang et al., 2010, I. longissimus Simonetta and Delle Cave, 1975, T. manchuriensis Resser and Endo in Resser, 1929, T. guntheri Robison and Richards, 1981 and a new species T. wudangshanensis sp. nov. The large bivalved arthropod assemblage from the upper Panchegou Member of the Zhangxia Formation (upper Drumian) represents the latest fossil record of Isoxys and Tuzoia worldwide. The first occurrences of I. longissimus and T. guntheri outside of Laurentia extend the known spatial and temporal distribution of these taxa, suggesting a strong paleobiogeographic affinity between North China and Laurentia.