Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses
文献类型：期刊论文
| 作者 | Yong Jian-ping; Aisa Haji Akber; Aisa, HA
|
| 刊名 | BULLETIN OF THE KOREAN CHEMICAL SOCIETY
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:4页码:1293-1297 |
| 关键词 | Synthesis Rupestonic acid ester derivatives Anti-influenza virus |
| ISSN号 | 0253-2964 |
| 通讯作者 | Aisa, HA |
| 英文摘要 | To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 21(IC50= 0.5 mu mol/L) exhibited potent anti-influenza A(3) viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC50 = 5.1 mu mol/L). |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000290366200035 |
| 公开日期 | 2013-11-07 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/2783]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 通讯作者 | Aisa, HA |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yong Jian-ping,Aisa Haji Akber,Aisa, HA. Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2011,32(4):1293-1297. |
| APA | Yong Jian-ping,Aisa Haji Akber,&Aisa, HA.(2011).Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,32(4),1293-1297. |
| MLA | Yong Jian-ping,et al."Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 32.4(2011):1293-1297. |
入库方式： OAI收割
来源：新疆理化技术研究所
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