Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta
文献类型：期刊论文
| 作者 | Senejoux Francois; Girard Corinne; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Demougeot Celine |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 132期号:1页码:268-273 |
| 关键词 | Ziziphora clinopodioides Lam. Uyghur Traditional medicine Hypertension Mechanisms Vasorelaxant |
| ISSN号 | 0378-8741 |
| 英文摘要 | Aim of the study: Ziziphora clinopodioides Lam. (ZC) is widely used in Uyghur folk medicine for the treatment of hypertension diseases in Xinjiang, an autonomous region of China. To provide pharmacological basis for this traditional use, we explored the vasodilating effects of ZC and investigated the underlying mechanisms. Materials and methods: Activity of hexane (ZCHE), dichloromethane (ZCDE) and aqueous (ZCAE) extracts of ZC were evaluated on isolated rat aortic rings pre-contracted with phenylephrine (PE) or high KCl. The mechanisms were evaluated on ZCDE, the most potent extract. Results: ZCDE-induced relaxation in endothelium-intact aortic rings pre-contracted with phenylephrine (PE, 10(-6) M) or high KCl (6 x 10(-2)M), with respective EC(50) values of 0.27 +/- 0.03 and 0.34 +/- 0.04g/l. Mechanic removal of the endothelium did not significantly modify ZCDE-induced relaxation. In endothelium-denuded aorta pre-contracted with PE (10(-6) M), the vasorelaxant effect of ZCDE was significantly decreased by 4-amino-pyridine (10(-3) M), but not by glibenclamide (10(-4)M), iberiotoxin (3 x 10(-8) M) and thapsigargin (10(-7) M). In Ca(2+) free solution, ZCDE significantly inhibited extracellular Ca(2+)-induced contraction in high KCl and PE pre-contracted rings. Additionally ZDCE inhibited the intracellular Ca(2+) release sensitive to PE (10(-6) M). Conclusions: The results demonstrate that ZDCE exhibits endothelium-independent vasodilating properties that are mediated by inhibition of extracellular Ca(2+) influx through voltage- and receptor-operated Ca2+ channels (VDDCs and ROCCs), by inhibition of Ca(2+) release from intracellular stores, and also by the opening of voltage-dependent K(+) channels. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 收录类别 | SCI |
| WOS记录号 | WOS:000284442100033 |
| 公开日期 | 2013-11-07 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/2818]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | UFR Sci Med & Pharmaceut, EA Sci Separat Biol & Pharmaceut 4267, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, Peoples R China;Chinese Acad Sci, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Senejoux Francois,Girard Corinne,Kerram Parhat,et al. Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,132(1):268-273. |
| APA | Senejoux Francois.,Girard Corinne.,Kerram Parhat.,Aisa Haji Akber.,Berthelot Alain.,...&Demougeot Celine.(2010).Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta.JOURNAL OF ETHNOPHARMACOLOGY,132(1),268-273. |
| MLA | Senejoux Francois,et al."Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta".JOURNAL OF ETHNOPHARMACOLOGY 132.1(2010):268-273. |
入库方式： OAI收割
来源：新疆理化技术研究所
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