Key factors in chaperonin-assisted protein folding
文献类型：期刊论文
| 作者 | Ren, Ying1; Gao, Jian1; Xu, Ji1,2; Ge, Wei1; Li, Jinghai1 |
| 刊名 | PARTICUOLOGY
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 10期号:1页码:105-116 |
| 关键词 | Molecular dynamics simulation Explicit solvent Chaperonin Protein folding |
| ISSN号 | 1674-2001 |
| 通讯作者 | Ren, Y |
| 英文摘要 | Incorrect folding of proteins in the macromolecular crowding environment in living cells would cause cellular disasters. All cells have developed their structurally and functionally distinct classes of molecular chaperones to help nonnative proteins fold to their native structures, one of which is the most studied GroEL/ES complex. In the present article, large-scale all-atom explicit solvent molecular dynamics (MD) simulations have been carried out on rhodanese folding in a series of chaperonin mutants for 200 ns to understand the mechanism therein. In accordance with experimental results, two factors have been identified to play a significant role, the geometrical confinement effect of the folding cavity and the charge effect of the inner surface of the cavity. Our analysis of the properties during simulation suggests that the GroEL/ES complex directly exerts force on the contacting residues of the substrate, thus assists substrate folding. (C) 2011 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | MOLECULAR-DYNAMICS ; SUBSTRATE PROTEIN ; GROEL ; SIMULATIONS ; POLYPEPTIDE ; BINDING ; CONFINEMENT ; THERMODYNAMICS ; ENHANCEMENT ; EVOLUTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301813900015 |
| 公开日期 | 2013-10-23 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3885]  |
| 专题 | 过程工程研究所_多相复杂系统国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Ying,Gao, Jian,Xu, Ji,et al. Key factors in chaperonin-assisted protein folding[J]. PARTICUOLOGY,2012,10(1):105-116. |
| APA | Ren, Ying,Gao, Jian,Xu, Ji,Ge, Wei,&Li, Jinghai.(2012).Key factors in chaperonin-assisted protein folding.PARTICUOLOGY,10(1),105-116. |
| MLA | Ren, Ying,et al."Key factors in chaperonin-assisted protein folding".PARTICUOLOGY 10.1(2012):105-116. |
入库方式： OAI收割
来源：过程工程研究所
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