Prediction of phase equilibrium of protein aqueous system
文献类型：会议论文
| 作者 | Zhang, X. P. ; He, X. Z. ; Li, C. S. ; Zhang, S. J. ; Dai, W. B. |
| 出版日期 | 2004 |
| 会议名称 | 4th International Conference on Separation Science and Technology (ICSST-04) |
| 会议日期 | FEB 18-21, 2004 |
| 会议地点 | Nanning, PEOPLES R CHINA |
| 关键词 | artificial neural-networks molecular thermodynamics solubility lysozyme crystals diagram growth |
| 页码 | 95-100 |
| 中文摘要 | Phase equilibrium calculation of thermodynamic system plays an important role in the separation and purification of many organic and inorganic materials. The phase diagram of protein aqueous system is predicted by the lattice thermodynamic model with parameters for the interaction between protein molecules in the liquid and in the solid phase. The essential features, such as liquid-liquid coexisting curve, spinodal curve and solubility curve were described based on the model reasonably. Also, the stable, unstable and metastable regions were shown clearly in the phase diagram. In the other hand, BP algorithm is proposed to simulate the solubility of protein in the salt aqueous and it would avoid the complexity of rigorous thermodynamic model and inaccuracy of estimation of interaction parameters. The results obtained with both of the approaches were compared with the experimental data. With predicted digital phase diagram, the protein crystallization process could be understood much intuitively and much flexibly. It offers a theoretical base for simulation and optimization of the crystallization process of proteins. |
| 收录类别 | CPCI |
| 会议网址 | |
| 会议录 | FRONTIERS ON SEPARATION SCIENCE AND TECHNOLOGY
 |
| 会议录出版者 | World Scientific Publ Co Pte Ltd |
| 语种 | 英语 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4987]  |
| 专题 | 过程工程研究所_多相复杂系统国家重点实验室 |
| 推荐引用方式 GB/T 7714 |
Zhang, X. P.,He, X. Z.,Li, C. S.,et al. Prediction of phase equilibrium of protein aqueous system[C]. 见:4th International Conference on Separation Science and Technology (ICSST-04). Nanning, PEOPLES R CHINA. FEB 18-21, 2004. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。