Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD)
文献类型：期刊论文
| 作者 | Lv, Pi-Ping1,3; Ma, Yu-Feng2; Yu, Rong2; Yue, Hua1; Ni, De-Zhi1,3; Wei, Wei1; Ma, Guang-Hui1 |
| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 9期号:6页码:1736-1747 |
| 关键词 | nanoparticles crystallization drug delivery RGD peptide |
| ISSN号 | 1543-8384 |
| 通讯作者 | Wei, W |
| 英文摘要 | Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In this study, we developed a tumor-targeting delivery system for insoluble drug (paclitaxel, PTX) by PEGylated O-carboxymethyl-chitosan (CMC) nanoparticles grafted with cyclic Arg-Gly-Asp (RGD) peptide. To improve the loading efficiency (LE), we combined O/W/O double emulsion method with temperature-programmed solidification technique and controlled PTX within the matrix network as in situ nanocrystallite form. Furthermore, these CMC nanoparticles were PEGylated, which could reduce recognition by the reticuloendothelial system (RES) and prolong the circulation time in blood. In addition, further graft of cyclic RGD peptide at the terminal of PEG chain endowed these nanoparticles with higher affinity to in vitro Lewis lung carcinoma (LLC) cells and in vivo tumor tissue. These outstanding properties enabled as-designed nanodevice to exhibit a greater tumor growth inhibition effect and much lower side effects over the commercial formulation Taxol. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | MEMBRANE EMULSIFICATION ; DRUG-DELIVERY ; MOUSE MODEL ; MICROSPHERES ; SYSTEMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304728700020 |
| 公开日期 | 2013-10-17 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3597]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Sichuan Univ, W China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Pi-Ping,Ma, Yu-Feng,Yu, Rong,et al. Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD)[J]. MOLECULAR PHARMACEUTICS,2012,9(6):1736-1747. |
| APA | Lv, Pi-Ping.,Ma, Yu-Feng.,Yu, Rong.,Yue, Hua.,Ni, De-Zhi.,...&Ma, Guang-Hui.(2012).Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD).MOLECULAR PHARMACEUTICS,9(6),1736-1747. |
| MLA | Lv, Pi-Ping,et al."Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD)".MOLECULAR PHARMACEUTICS 9.6(2012):1736-1747. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。