Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM)
文献类型：期刊论文
| 作者 | Zhang, Yun-jian1; Li, Qiang2; Zhang, Yu-xiu1; Wang, Dan2; Xing, Jian-min2 |
| 刊名 | JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 13期号:2页码:103-110 |
| 关键词 | Succinic acid Response surface methodology (RSM) Optimization Actinobacillus succinogenes |
| ISSN号 | 1673-1581 |
| 通讯作者 | Zhang, YX |
| 英文摘要 | Succinic acid is considered as an important platform chemical. Succinic acid fermentation with Actinobacillus succinogenes strain BE-1 was optimized by central composite design (CCD) using a response surface methodology (RSM). The optimized production of succinic acid was predicted and the interactive effects between glucose, yeast extract, and magnesium carbonate were investigated. As a result, a model for predicting the concentration of succinic acid production was developed. The accuracy of the model was confirmed by the analysis of variance (ANOVA), and the validity was further proved by verification experiments showing that percentage errors between actual and predicted values varied from 3.02% to 6.38%. In addition, it was observed that the interactive effect between yeast extract and magnesium carbonate was statistically significant. In conclusion, RSM is an effective and useful method for optimizing the medium components and investigating the interactive effects, and can provide valuable information for succinic acid scale-up fermentation using A. succinogenes strain BE-1. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 关键词[WOS] | MEDIUM COMPONENTS ; ANAEROBIOSPIRILLUM-SUCCINICIPRODUCENS ; STATISTICAL APPROACH ; PARAMETERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301453900003 |
| 公开日期 | 2013-10-23 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3905]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.China Univ Min & Technol Beijing, Sch Chem & Environm Engn, Beijing 100083, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yun-jian,Li, Qiang,Zhang, Yu-xiu,et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM)[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2012,13(2):103-110. |
| APA | Zhang, Yun-jian,Li, Qiang,Zhang, Yu-xiu,Wang, Dan,&Xing, Jian-min.(2012).Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM).JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,13(2),103-110. |
| MLA | Zhang, Yun-jian,et al."Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM)".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 13.2(2012):103-110. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。