Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions
文献类型：期刊论文
| 作者 | Jia, Lianwei1,2; Guo, Chen1; Xiang, Junfeng3; Wang, Ning1,2; Yang, Liangrong1; Tang, Yalin3; Liu, Huizhou1 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2012-01-24 |
| 卷号 | 28期号:3页码:1725-1732 |
| 关键词 | NUCLEAR-MAGNETIC-RESONANCE PLURONIC((R)) BLOCK-COPOLYMERS BIOLOGICAL RESPONSE MODIFIERS HORMONE-RELEASING PEPTIDES DRUG-DELIVERY SYSTEMS TRIBLOCK COPOLYMERS PROTEIN ADSORPTION GENE DELIVERY POLYMER THERAPEUTICS SPECTROSCOPY |
| ISSN号 | 0743-7463 |
| 通讯作者 | Guo, C |
| 英文摘要 | Interaction between PEO-PPO-PEO copolymers and a hexapeptide, growth hormone releasing peptide-6 (GHRP-6), was investigated by NMR to study the potential use of the copolymers in peptide drug delivery. H-1 NMR and nuclear Overhauser effect spectroscopy (NOESY) measurements determined that PO methyl protons interacted with methyl protons of the Ala moiety, aromatic protons of the Tip moiety, and some of the Phe aromatic protons. The Lys moiety and part of the Phe moiety entered the hydrophilic EO environment via hydrogen bonding. PEO PPO PEO copolymers and the peptide formed a complex in 1:1 stoichiometry. Binding constants between copolymers and GHRP-6 were determined, and it was indicated that the copolymers containing more EO and PO units will lead to greater affinity with the peptide. Isothermal titration calorimetry (ITC) measurements confirmed the results of NMR experiments. This study indicates that PEO-PPO-PEO copolymers have great potential in delivering peptide drugs. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Materials Science |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; PLURONIC((R)) BLOCK-COPOLYMERS ; BIOLOGICAL RESPONSE MODIFIERS ; HORMONE-RELEASING PEPTIDES ; DRUG-DELIVERY SYSTEMS ; TRIBLOCK COPOLYMERS ; PROTEIN ADSORPTION ; GENE DELIVERY ; POLYMER THERAPEUTICS ; SPECTROSCOPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299366500010 |
| 公开日期 | 2013-10-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4317]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Ctr Mol Sci,Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Lianwei,Guo, Chen,Xiang, Junfeng,et al. Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions[J]. LANGMUIR,2012,28(3):1725-1732. |
| APA | Jia, Lianwei.,Guo, Chen.,Xiang, Junfeng.,Wang, Ning.,Yang, Liangrong.,...&Liu, Huizhou.(2012).Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions.LANGMUIR,28(3),1725-1732. |
| MLA | Jia, Lianwei,et al."Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions".LANGMUIR 28.3(2012):1725-1732. |
入库方式： OAI收割
来源：过程工程研究所
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