In vitro antioxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis
文献类型：期刊论文
| 作者 | Zhao, Qingsheng1,2; Xie, Bingxian3; Yan, Jun3,4; Zhao, Fangchun1,2; Xiao, Jie1,2; Yao, Lingyun1,2; Zhao, Bing1; Huang, Yunxiang5 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2012-01-04 |
| 卷号 | 87期号:1页码:392-396 |
| 关键词 | Asparagus officinalis Polysaccharides Ethanol fractional precipitation Antioxidant Antitumor |
| ISSN号 | 0144-8617 |
| 通讯作者 | Zhao, B |
| 英文摘要 | Ultrasonic circulating extraction technology was applied for the polysaccharide extraction from Asparagus officinalis. The crude polysaccharides were deproteinized by Sevag method and three main polysaccharide fractions, AOP-4. AOP-6 and AOP-8 were obtained by fractional precipitation with gradient concentrations of ethanol (40%, 60% and 80%). The in vitro antitumor and antioxidant activities of the polysaccharide fractions were evaluated by MTT assay and free radical-scavenging assay, respectively. Deproteinized AOPs showed higher antioxidant and antitumor activities than crude AOP. AOP-4 with molecular weight 5.75 x 10(4) Da showed significant function of scavenging hydroxyl radical. Three AOP fractions had significant antitumor activity against HeLa and BEL-7404 cells in a dose dependent manner. Furthermore, the inhibit activity of AOP-4 against HeLa cells was higher than those of other AOPs and the inhibition rate reached 83.96% at the concentration of 10 mg/mL. These results indicated that the AOP might be useful for developing natural safe antitumor drugs or health food. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Polymer Science |
| 关键词[WOS] | PRINCIPLE ; FOOD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297389000052 |
| 公开日期 | 2013-10-29 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4345]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Nanjing Univ, MOE Key Lab Model Anim Dis Study, Model Anim Res Ctr, Nanjing 210061, Peoples R China 4.Wenzhou Med Coll, Sch Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China 5.Qinhuangdao Chang Shang Agr Sci & Technol Co Ltd, Qinhuangdao 066006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qingsheng,Xie, Bingxian,Yan, Jun,et al. In vitro antioxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis[J]. CARBOHYDRATE POLYMERS,2012,87(1):392-396. |
| APA | Zhao, Qingsheng.,Xie, Bingxian.,Yan, Jun.,Zhao, Fangchun.,Xiao, Jie.,...&Huang, Yunxiang.(2012).In vitro antioxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis.CARBOHYDRATE POLYMERS,87(1),392-396. |
| MLA | Zhao, Qingsheng,et al."In vitro antioxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis".CARBOHYDRATE POLYMERS 87.1(2012):392-396. |
入库方式： OAI收割
来源：过程工程研究所
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