Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration
文献类型：期刊论文
| 作者 | Lv, Pi-Ping1,2; Wei, Wei1; Yue, Hua1,2; Yang, Ting-Yuan1; Wang, Lian-Yan1; Ma, Guang-Hui1 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 12期号:12页码:4230-4239 |
| 关键词 | DRUG-DELIVERY MEMBRANE EMULSIFICATION PROTEIN DRUG MICROSPHERES ENCAPSULATION APOPTOSIS MICELLES ANTIGEN |
| ISSN号 | 1525-7797 |
| 通讯作者 | Ma, GH |
| 英文摘要 | Clinical application of paclitaxel (PTX) is limited because of its poor solubility in aqueous media. To overcome this hurdle, we devised an oral delivery system by encapsulating PTX into N-((2-hydroxy-3-trimethylammonium) propyl) chitosan chloride (HTCC) nanoparticles. These nanoparticles were small (similar to 130 nm), had a narrow size distribution, and displayed high loading efficiency owing to the homogeneous distribution of PTX nanocrystals. The matrix hydrophilicity and porous structure of the obtained nanoparticles accelerated their degradation and improved drug release. In vitro and in vivo transport experiments had proved that the presence of positive charges enhanced the intestinal permeability of these nanoparticles. Further in vitro experiment of cytotoxicity showed that the PTX-loaded HTCC nanoparticle (HTCC-NP:PTX) was more effective than native PTX owing to enhanced cellular uptake. Drug distribution in tissues and in vivo imaging studies confirmed the preferred accumulation of HTCC-NP:PTX in subcutaneous tumor tissue. Subsequent tumor xenograft assays demonstrated the promising therapeutic effect of HTCC-NP:PTX on inhibition of tumor growth and induction of apoptosis in tumor cells. Additional investigation into side effects revealed that HTCC-NP:PTX caused lower Cremophor EL-associated toxicities compared with Taxol. These results strongly supported the notion that HTCC nanoparticle (HTCC-NP) is a promising candidate as an oral carrier of FIX for cancer therapy. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 关键词[WOS] | DRUG-DELIVERY ; MEMBRANE EMULSIFICATION ; PROTEIN DRUG ; MICROSPHERES ; ENCAPSULATION ; APOPTOSIS ; MICELLES ; ANTIGEN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297782100008 |
| 公开日期 | 2013-10-29 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4346]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Pi-Ping,Wei, Wei,Yue, Hua,et al. Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration[J]. BIOMACROMOLECULES,2011,12(12):4230-4239. |
| APA | Lv, Pi-Ping,Wei, Wei,Yue, Hua,Yang, Ting-Yuan,Wang, Lian-Yan,&Ma, Guang-Hui.(2011).Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration.BIOMACROMOLECULES,12(12),4230-4239. |
| MLA | Lv, Pi-Ping,et al."Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration".BIOMACROMOLECULES 12.12(2011):4230-4239. |
入库方式： OAI收割
来源：过程工程研究所
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