Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs
文献类型：期刊论文
| 作者 | Yue, Zhan-Guo1,2; Wei, Wei1; You, Zuo-Xiang1,3; Yang, Qin-Zheng3; Yue, Hua1,2; Su, Zhi-Guo1; Ma, Guang-Hui1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2011-09-23 |
| 卷号 | 21期号:18页码:3446-3453 |
| 关键词 | IN-VIVO EVALUATION BIOMEDICAL APPLICATIONS POLYMERIC MICELLES HYDROPHOBIC DRUGS NANOPARTICLES PACLITAXEL THERAPY VITRO COPOLYMER DESIGN |
| ISSN号 | 1616-301X |
| 通讯作者 | Yue, ZG |
| 英文摘要 | Low solubility in water is an intrinsic property of many drugs, which hinders the clinical use of those active ingredients. To break this bottleneck, we attempt to develop an iron oxide nanoparticle-based multifunctional system. Firstly, we perform PEG coating and compare the feasibility of spherical and rod-like iron oxide nanoparticles in a view of carcinoma cellular uptake; rod-like nanoparticles attracted our interest since they could be quickly and massively internalized. For paclitaxel (PTX) loading, we next transform the nanorods into a tube structure by a hydrothermal method. The results show that drug crystals can be successfully loaded in the inner voids of these nanotubes (PMNTs) by controlling the crystallization process of PTX. The acquired nanocomplexes not only escape phagocytosis of macrophage cells by a PEG stealth effect, but also exhibit an increased cellular uptake with magnetic field exposure. In addition, this iron oxide-based drug carrier possesses a low pH-activated release profile, which would accelerate drug release in the carcinoma cells and minimize non-specific drug release. Owing to these advantages, PMNTs promote the anticancer efficacy of PTX and clearly exhibit promising potential for using as high-efficiency insoluble drug delivery system in clinical applications. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | IN-VIVO EVALUATION ; BIOMEDICAL APPLICATIONS ; POLYMERIC MICELLES ; HYDROPHOBIC DRUGS ; NANOPARTICLES ; PACLITAXEL ; THERAPY ; VITRO ; COPOLYMER ; DESIGN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295223500007 |
| 公开日期 | 2013-10-30 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4577]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Shandong Inst Light Ind, Coll Food & Bioengn, Jinan 250353, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Zhan-Guo,Wei, Wei,You, Zuo-Xiang,et al. Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs[J]. ADVANCED FUNCTIONAL MATERIALS,2011,21(18):3446-3453. |
| APA | Yue, Zhan-Guo.,Wei, Wei.,You, Zuo-Xiang.,Yang, Qin-Zheng.,Yue, Hua.,...&Ma, Guang-Hui.(2011).Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs.ADVANCED FUNCTIONAL MATERIALS,21(18),3446-3453. |
| MLA | Yue, Zhan-Guo,et al."Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs".ADVANCED FUNCTIONAL MATERIALS 21.18(2011):3446-3453. |
入库方式： OAI收割
来源：过程工程研究所
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