A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release
文献类型：期刊论文
| 作者 | Wang, Chan1; Lv, Piping2; Wei, Wei2; Tao, Shengyang1; Hu, Tao1; Yang, Jingbang1; Meng, Changgong1 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2011-10-14 |
| 卷号 | 22期号:41页码:Article Number: 415101 |
| 关键词 | MODIFIED MESOPOROUS SILICA FOLATE RECEPTOR BIOMEDICAL APPLICATIONS MAGNETIC NANOPARTICLES GUEST MOLECULES CANCER-CELLS SHELL CORE ACID NANOCONTAINERS |
| ISSN号 | 0957-4484 |
| 通讯作者 | Wang, C |
| 英文摘要 | A multifunctional 'all-in-one' nanocomposite is fabricated using a colloid, template and surface-modification method. This material encompasses magnetic induced target delivery, cell uptake promotion and controlled drug release in one system. The nanocomposite is characterized by scanning electron microscopy, transmission electron microscopy, x-ray diffraction, N(2) adsorption and vibrating sample magnetometry. The prepared material has a diameter of 350-400 nm, a high surface area of 420.29 m(2) g(-1), a pore size of 1.91 nm and a saturation magnetization of 32 emu g(-1). Doxorubicin (DOX) is loaded in mesopores and acid-sensitive blockers are introduced onto the orifices of the mesopores by a Schiff base linker to implement pH-dependent self-release. Folate was also introduced to improve DOX targeted delivery and endocytosis. The linkers remained intact to block pores with ferrocene valves and inhibit the diffusion of DOX at neutral pH. However, in lysosomes of cancer cells, which have a weak acidic pH, hydrolysis of the Schiff base group removes the nanovalves and allows the trapped DOX to be released. These processes are demonstrated by UV-visible absorption spectra, confocal fluorescence microscopy images and methyl thiazolyl tetrazolium assays in vitro, which suggest that the smart nanocomposite successfully integrates targeted drug delivery with internal stimulus induced self-release and is a potentially useful material for nanobiomedicine. |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | MODIFIED MESOPOROUS SILICA ; FOLATE RECEPTOR ; BIOMEDICAL APPLICATIONS ; MAGNETIC NANOPARTICLES ; GUEST MOLECULES ; CANCER-CELLS ; SHELL ; CORE ; ACID ; NANOCONTAINERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295163900001 |
| 公开日期 | 2013-10-30 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4583]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Dalian Univ Technol, Sch Chem Engn, Dalian, Liaoning, Peoples R China 2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chan,Lv, Piping,Wei, Wei,et al. A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release[J]. NANOTECHNOLOGY,2011,22(41):Article Number: 415101. |
| APA | Wang, Chan.,Lv, Piping.,Wei, Wei.,Tao, Shengyang.,Hu, Tao.,...&Meng, Changgong.(2011).A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release.NANOTECHNOLOGY,22(41),Article Number: 415101. |
| MLA | Wang, Chan,et al."A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release".NANOTECHNOLOGY 22.41(2011):Article Number: 415101. |
入库方式： OAI收割
来源：过程工程研究所
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