Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method
文献类型：期刊论文
| 作者 | Zhang, Yong1,2; Cong, Wei1; Shi, Shao Yuan1 |
| 刊名 | BIOPROCESS AND BIOSYSTEMS ENGINEERING
 |
| 出版日期 | 2011 |
| 卷号 | 34期号:1页码:67-73 |
| 关键词 | Lactic acid Packed bed-stirred fermentor pH feedback Recirculation Lactobacillus lactis-11 |
| ISSN号 | 1615-7591 |
| 通讯作者 | Cong, W |
| 英文摘要 | Lactic acid production by repeated fed-batch fermentation using free and immobilized cells of Lactobacillus lactis-11 in a packed bed-stirred fermentor (PBSF) system filled with different support materials including ceramic beads, macro-activated carbon cylinders and glass fiber balls was investigated. The results showed that the optimal support materials were the ceramic beads with diameters of 1-2 mm. Compared with the free cell fermentation system, lactic acid production and volumetric productivity in the PBSF system increased by 16.6 and 12.5%, respectively. Though the concentration of free cells decreased sharply, lactic acid production remained stable in five consecutive fed-batch runs using the PBSF system. pH gradients, immobilized cell concentration and mass diffusion in the packed bed were all affected by the recirculation rate of the culture broth. Maximum lactic acid production, productivity and yield occurred at a recirculation rate of 50 mL min(-1). |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Engineering, Chemical |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Engineering |
| 关键词[WOS] | IMMOBILIZED LACTOBACILLUS-CASEI ; WHEY PERMEATE ; PROPIONATE PRODUCTION ; RHIZOPUS-ORYZAE ; FLUIDIZED-BED ; BIOREACTOR ; CELLS ; HELVETICUS ; SUPPORTS ; CULTURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285786300007 |
| 公开日期 | 2013-11-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5382]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yong,Cong, Wei,Shi, Shao Yuan. Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method[J]. BIOPROCESS AND BIOSYSTEMS ENGINEERING,2011,34(1):67-73. |
| APA | Zhang, Yong,Cong, Wei,&Shi, Shao Yuan.(2011).Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method.BIOPROCESS AND BIOSYSTEMS ENGINEERING,34(1),67-73. |
| MLA | Zhang, Yong,et al."Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method".BIOPROCESS AND BIOSYSTEMS ENGINEERING 34.1(2011):67-73. |
入库方式： OAI收割
来源：过程工程研究所
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