Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity
文献类型：期刊论文
| 作者 | Liu, Xiangyou1,2,3; Wei, Wei4; Wang, Chunlei5; Yue, Hua4; Ma, Ding1; Zhu, Cheng1; Ma, Guanghui4; Du, Yuguang2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:20页码:7105-7110 |
| 关键词 | HORSE SPLEEN APOFERRITIN PLATINUM NANOPARTICLE PROTEIN CAGES IRON RELEASE FERRITIN CELLS BIOCOMPATIBILITY LIVER |
| ISSN号 | 0959-9428 |
| 通讯作者 | Ma, D |
| 英文摘要 | Apoferritin-encapsulated Pt nanoparticles (AFt-Pt) were bio-mimetically prepared by an in situ reduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt-Pt was 4.3 +/- 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times via receptor-mediated endocytosis. AFt-Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP-Pt). More than 80% of cells survived after treatment with 100 mM AFt-Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Physical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Materials Science |
| 关键词[WOS] | HORSE SPLEEN APOFERRITIN ; PLATINUM NANOPARTICLE ; PROTEIN CAGES ; IRON RELEASE ; FERRITIN ; CELLS ; BIOCOMPATIBILITY ; LIVER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290167200010 |
| 公开日期 | 2013-11-11 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5395]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 5.Dalian Univ Technol, Sch Chem Engn, Carbon Res Lab, Dalian 116024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiangyou,Wei, Wei,Wang, Chunlei,et al. Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(20):7105-7110. |
| APA | Liu, Xiangyou.,Wei, Wei.,Wang, Chunlei.,Yue, Hua.,Ma, Ding.,...&Du, Yuguang.(2011).Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity.JOURNAL OF MATERIALS CHEMISTRY,21(20),7105-7110. |
| MLA | Liu, Xiangyou,et al."Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity".JOURNAL OF MATERIALS CHEMISTRY 21.20(2011):7105-7110. |
入库方式： OAI收割
来源：过程工程研究所
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