Cross-linked inulin as a potential plasma expander: Biochemical properties and physiological characterization in a rabbit model
文献类型：期刊论文
| 作者 | Li, Suping1,2; Hu, Tao1; Chen, Yali1; Zheng, Chunyang1; Liu, Tao1,2; Ma, Guanghui1; Su, Zhiguo1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2010-11-11 |
| 卷号 | 82期号:4页码:1054-1060 |
| 关键词 | Hydroxyethyl starch Inulin Colloid osmotic pressure Mean artery pressure |
| ISSN号 | 0144-8617 |
| 通讯作者 | Su, ZG |
| 英文摘要 | Inulin, a plant-source polysaccharide, was cross-linked and evaluated as a new potential plasma expander in vitro and in vivo. The cross-linked inulin (CLI) in three different molecular sizes (54, 100 and 146 kDa) was characterized by gel filtration chromatography coupled with multi-angle laser light scattering. Their in vivo physiological properties, including blood pressure and organ function, were tested in a rabbit model. Compared to the other two CLI samples, the CLI2 with a molecular weight (M(w)) of 100 kDa is advisable as a potential plasma expander for its strong expansion efficacy and no organ dysfunction. Moreover, CLI2 showed a high colloid osmotic pressure (COP) where the COP of 3% CLI2 is equal to that of 6% HES. Thus, much less CLI2 can be infused with the same effects as normal HES, and its potential side effects can be minimized. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Polymer Science |
| 关键词[WOS] | HYDROXYETHYL STARCH ; VOLUME REPLACEMENT ; HEMORRHAGIC-SHOCK ; SUBSTITUTES ; ALBUMIN ; MICROCIRCULATION ; EXPANSION ; CARRIERS ; GELATIN ; SEPSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283042100005 |
| 公开日期 | 2013-11-12 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5573]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Suping,Hu, Tao,Chen, Yali,et al. Cross-linked inulin as a potential plasma expander: Biochemical properties and physiological characterization in a rabbit model[J]. CARBOHYDRATE POLYMERS,2010,82(4):1054-1060. |
| APA | Li, Suping.,Hu, Tao.,Chen, Yali.,Zheng, Chunyang.,Liu, Tao.,...&Su, Zhiguo.(2010).Cross-linked inulin as a potential plasma expander: Biochemical properties and physiological characterization in a rabbit model.CARBOHYDRATE POLYMERS,82(4),1054-1060. |
| MLA | Li, Suping,et al."Cross-linked inulin as a potential plasma expander: Biochemical properties and physiological characterization in a rabbit model".CARBOHYDRATE POLYMERS 82.4(2010):1054-1060. |
入库方式： OAI收割
来源：过程工程研究所
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