Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
文献类型：期刊论文
| 作者 | Liu, Chunzhao; Zhao, Yan; Wang, Yuchun |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 72期号:1页码:11-20 |
| 关键词 | hairy root cultures tumefaciens-mediated transformation farnesyl diphosphate synthase mevalonate-independent pathway annua l escherichia-coli isoprenoid biosynthesis amorpha-4 arteannuin-b qinghaosu artemisinin 11-diene synthase |
| ISSN号 | 0175-7598 |
| 其他题名 | Appl. Microbiol. Biotechnol. |
| 中文摘要 | Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology. |
| 英文摘要 | Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | HAIRY ROOT CULTURES ; TUMEFACIENS-MEDIATED TRANSFORMATION ; FARNESYL DIPHOSPHATE SYNTHASE ; MEVALONATE-INDEPENDENT PATHWAY ; ANNUA L ; ESCHERICHIA-COLI ; ISOPRENOID BIOSYNTHESIS ; AMORPHA-4,11-DIENE SYNTHASE ; ARTEANNUIN-B ; QINGHAOSU ARTEMISININ |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000239725100002 |
| 公开日期 | 2013-10-24 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3929]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Chunzhao,Zhao, Yan,Wang, Yuchun. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2006,72(1):11-20. |
| APA | Liu, Chunzhao,Zhao, Yan,&Wang, Yuchun.(2006).Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,72(1),11-20. |
| MLA | Liu, Chunzhao,et al."Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 72.1(2006):11-20. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。