Impurity effects on the crystallization of avermectin B1a
文献类型：期刊论文
| 作者 | Liu, J; Chang, ZD; Sun, XH; Shen, SF; Lei, C; Liu, HZ |
| 刊名 | JOURNAL OF CRYSTAL GROWTH
 |
| 出版日期 | 2006-06-01 |
| 卷号 | 291期号:2页码:448-454 |
| 关键词 | avermectin crystallization crystal morphology impurities impurity incorporation nucleation |
| ISSN号 | 0022-0248 |
| 其他题名 | J. Cryst. Growth |
| 中文摘要 | Impurities cannot readily be removed during crystallization of avermectin B1a. This study aims to investigate the main impurity effects on the crystallization of avermectin B1a. Impurities, A1a, A2a, B2a and saccharides, were isolated from avermectins crude powder by adsorption column chromatography. Impurity effects on nucleation rate, crystal morphology, and purity of crystals were studied by varying the amount of impurity (0-26.1%, w/w) as well as the relative supersaturation ratio (S, 1.8-2.8). Results showed that A1a, A2a and B2a suppressed primary nucleation. Saccharides promoted nucleation at low supersaturation, while they slightly inhibited nucleation at high supersaturation. A2a and B2a had a marked effect on the crystal morphology, while Ala and the saccharides did not show any significant effect on the crystal morphology. A1a, A2a and B2a could be incorporated into the growing crystals due to the similarity of their structure with the host molecule. (c) 2006 Elsevier B.V. All rights reserved. |
| 英文摘要 | Impurities cannot readily be removed during crystallization of avermectin B1a. This study aims to investigate the main impurity effects on the crystallization of avermectin B1a. Impurities, A1a, A2a, B2a and saccharides, were isolated from avermectins crude powder by adsorption column chromatography. Impurity effects on nucleation rate, crystal morphology, and purity of crystals were studied by varying the amount of impurity (0-26.1%, w/w) as well as the relative supersaturation ratio (S, 1.8-2.8). Results showed that A1a, A2a and B2a suppressed primary nucleation. Saccharides promoted nucleation at low supersaturation, while they slightly inhibited nucleation at high supersaturation. A2a and B2a had a marked effect on the crystal morphology, while Ala and the saccharides did not show any significant effect on the crystal morphology. A1a, A2a and B2a could be incorporated into the growing crystals due to the similarity of their structure with the host molecule. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Crystallography ; Materials Science, Multidisciplinary ; Physics, Applied |
| 研究领域[WOS] | Crystallography ; Materials Science ; Physics |
| 关键词[WOS] | KINETICS ; FERMENTATION ; SULFATE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000238525200022 |
| 公开日期 | 2013-10-24 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3996]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Lab Separat Sci & Engn, State Key Lab Biochem Engn, Inst Proc Engn,Grad Sch,Chinese Acad Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, J,Chang, ZD,Sun, XH,et al. Impurity effects on the crystallization of avermectin B1a[J]. JOURNAL OF CRYSTAL GROWTH,2006,291(2):448-454. |
| APA | Liu, J,Chang, ZD,Sun, XH,Shen, SF,Lei, C,&Liu, HZ.(2006).Impurity effects on the crystallization of avermectin B1a.JOURNAL OF CRYSTAL GROWTH,291(2),448-454. |
| MLA | Liu, J,et al."Impurity effects on the crystallization of avermectin B1a".JOURNAL OF CRYSTAL GROWTH 291.2(2006):448-454. |
入库方式： OAI收割
来源：过程工程研究所
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