Process integration for production of 6-aminnopenicillanic acid from penicillin G fermentation broth
文献类型：期刊论文
| 作者 | Shen, SF; Chang, ZD; Sun, XH; Liu, HZ |
| 刊名 | PROCESS BIOCHEMISTRY
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 41期号:3页码:571-574 |
| 关键词 | 6-aminnopenicillanic acid (6-APA) process integration three-liquid-phase extraction solvent sublation penicillin G ethylene oxide-propylene oxide (EOPO) random copolymer |
| ISSN号 | 1359-5113 |
| 其他题名 | Process Biochem. |
| 中文摘要 | A novel process for 6-aminnopenicillanic acid (6-APA) production from penicillin G fermentation broth was developed, which integrated some new technologies such as three-liquid-phase extraction and solvent sublation. A new three-liquid-phase extraction system containing ethylene oxide-propylene oxide (EOPO) random copolymer was used to separate and purify penicillin G from its filtrated broth and trace organic extractant in the aqueous phase of back-extraction was removed by solvent sublation. Experimental results showed that above 90% of penicillin G could be distributed into the upper organic phase at pH below 3.0, and most of impurities and some phenylacetic acids (PAA) were partitioned into the copolymer-rich middle phase. About 70% organic solvent could be stripped by one-step solvent sublation from penicillin G aqueous solution. The purity of 6-APA produced by the above-simplified process could be above 98% and other quality parameters reached the level of the conventional process. (c) 2005 Elsevier Ltd. All rights reserved. |
| 英文摘要 | A novel process for 6-aminnopenicillanic acid (6-APA) production from penicillin G fermentation broth was developed, which integrated some new technologies such as three-liquid-phase extraction and solvent sublation. A new three-liquid-phase extraction system containing ethylene oxide-propylene oxide (EOPO) random copolymer was used to separate and purify penicillin G from its filtrated broth and trace organic extractant in the aqueous phase of back-extraction was removed by solvent sublation. Experimental results showed that above 90% of penicillin G could be distributed into the upper organic phase at pH below 3.0, and most of impurities and some phenylacetic acids (PAA) were partitioned into the copolymer-rich middle phase. About 70% organic solvent could be stripped by one-step solvent sublation from penicillin G aqueous solution. The purity of 6-APA produced by the above-simplified process could be above 98% and other quality parameters reached the level of the conventional process. (c) 2005 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering, Chemical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering |
| 关键词[WOS] | 6-AMINOPENICILLANIC ACID ; 3-PHASE EXTRACTION ; ACYLASE ; SYSTEM ; POLYMER ; WATER |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000235727700011 |
| 公开日期 | 2013-10-24 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4056]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Lab Separat Sci & Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, SF,Chang, ZD,Sun, XH,et al. Process integration for production of 6-aminnopenicillanic acid from penicillin G fermentation broth[J]. PROCESS BIOCHEMISTRY,2006,41(3):571-574. |
| APA | Shen, SF,Chang, ZD,Sun, XH,&Liu, HZ.(2006).Process integration for production of 6-aminnopenicillanic acid from penicillin G fermentation broth.PROCESS BIOCHEMISTRY,41(3),571-574. |
| MLA | Shen, SF,et al."Process integration for production of 6-aminnopenicillanic acid from penicillin G fermentation broth".PROCESS BIOCHEMISTRY 41.3(2006):571-574. |
入库方式： OAI收割
来源：过程工程研究所
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