Docking study of HDAC implication for benzamide inhibitors binding mode
文献类型：期刊论文
| 作者 | Xie, AH; Li, BY; Liao, CZ; Li, ZB; Lu, XP; Shi, LM; Zhou, JJ |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2004-06-01 |
| 卷号 | 20期号:6页码:569-572 |
| 关键词 | histone deacetylase(HDAC) histone deacetylase like protein(HDLP) trichostatin A (TSA) docking MS-275 |
| ISSN号 | 1000-6818 |
| 其他题名 | Acta Phys.-Chim. Sin. |
| 中文摘要 | The paper proposed a possible binding mode of MS-275, a benzamide historic deacetylase(HDAC) inhibitor, to HDAC by intensive docking study. This binding mode is different from those observed in the crystal structure of complexes formed by a histone deacetylase-like protein (HDLP) with trichostatin A(TSA) or suberoylanilide hydroxamic acid (SARA). The docking result implicates that the main target of MS-275 is the narrowest part of HDAC active pocket. It seems to be able to explain the low toxicity of MS-275 and provides new insights on the design of novel HDAC inhibitors. |
| 英文摘要 | The paper proposed a possible binding mode of MS-275, a benzamide historic deacetylase(HDAC) inhibitor, to HDAC by intensive docking study. This binding mode is different from those observed in the crystal structure of complexes formed by a histone deacetylase-like protein (HDLP) with trichostatin A(TSA) or suberoylanilide hydroxamic acid (SARA). The docking result implicates that the main target of MS-275 is the narrowest part of HDAC active pocket. It seems to be able to explain the low toxicity of MS-275 and provides new insights on the design of novel HDAC inhibitors. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | HISTONE DEACETYLASE ; ACID ; TRANSCRIPTION ; ACETYLATION ; LEUKEMIA |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000222223400003 |
| 公开日期 | 2013-11-05 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4917]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China 2.Chipscreen Biosci Ltd, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, AH,Li, BY,Liao, CZ,et al. Docking study of HDAC implication for benzamide inhibitors binding mode[J]. ACTA PHYSICO-CHIMICA SINICA,2004,20(6):569-572. |
| APA | Xie, AH.,Li, BY.,Liao, CZ.,Li, ZB.,Lu, XP.,...&Zhou, JJ.(2004).Docking study of HDAC implication for benzamide inhibitors binding mode.ACTA PHYSICO-CHIMICA SINICA,20(6),569-572. |
| MLA | Xie, AH,et al."Docking study of HDAC implication for benzamide inhibitors binding mode".ACTA PHYSICO-CHIMICA SINICA 20.6(2004):569-572. |
入库方式： OAI收割
来源：过程工程研究所
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