A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin
文献类型：期刊论文
| 作者 | Yun, Q; He, ML; Xing, WC; Bi, JX; Ma, GH; Su, ZG |
| 刊名 | BIOTECHNOLOGY LETTERS
 |
| 出版日期 | 2004-09-01 |
| 卷号 | 26期号:17页码:1359-1363 |
| 关键词 | blood substitute bovine hemoglobin cross-linking reagent modification |
| ISSN号 | 0141-5492 |
| 其他题名 | Biotechnol. Lett. |
| 中文摘要 | A novel tetrafunctional reagent, alpha, gamma, alpha', gamma'-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSU)(4)), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoc,lobin showed a slight decrease in half-saturated O-2 pressure value (P-50, from 28.1 mm Hg to 21.7 mm Hg) and Ell coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O-2 delivery. |
| 英文摘要 | A novel tetrafunctional reagent, alpha, gamma, alpha', gamma'-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSU)(4)), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoc,lobin showed a slight decrease in half-saturated O-2 pressure value (P-50, from 28.1 mm Hg to 21.7 mm Hg) and Ell coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O-2 delivery. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | BLOOD SUBSTITUTE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000225103700008 |
| 公开日期 | 2013-11-05 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4975]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yun, Q,He, ML,Xing, WC,et al. A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin[J]. BIOTECHNOLOGY LETTERS,2004,26(17):1359-1363. |
| APA | Yun, Q,He, ML,Xing, WC,Bi, JX,Ma, GH,&Su, ZG.(2004).A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin.BIOTECHNOLOGY LETTERS,26(17),1359-1363. |
| MLA | Yun, Q,et al."A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin".BIOTECHNOLOGY LETTERS 26.17(2004):1359-1363. |
入库方式： OAI收割
来源：过程工程研究所
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