Preparation of microspheres with microballoons inside for floating drug-delivery systems
文献类型：期刊论文
| 作者 | Yang, ZQ; Song, BZ; Li, QX; Fan, HL; Fan, OY |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2004-10-05 |
| 卷号 | 94期号:1页码:197-202 |
| 关键词 | polysaccharides drug delivery systems microencapsulation particle size distribution |
| ISSN号 | 0021-8995 |
| 其他题名 | J. Appl. Polym. Sci. |
| 中文摘要 | The use of floating drug-delivery systems is one method that is used to achieve prolonged gastric residence times. We developed a novel, multiple-unit, floating drug-delivery system of microspheres with microballoons inside from xanthan gum (XG) and gelatin (GA) by a water-in-oil method. With theophylline as the model drug, four formulations (FI-FIV) with different ratios of the two polymers were prepared. The size distribution, drug-encapsulation efficiency, floating behavior, release characteristics, and morphological properties were investigated. The ratio of the two polymers influenced the size distribution, encapsulation efficiency, and drug release appreciably. With increasing amounts of GA, the percentage yield of the floating microspheres and the drug-encapsulation efficiency decreased from 100 and 84.5% to 31 and 56.2%, respectively. The drug-release rate also decreased with increasing GA content, which was attributed to an increase in the crosslinking extent. An initial burst was observed, and after that, the drug was released slowly by a near-zero-order pattern, which was attributed to the low solubility of theophylline and the possible complexes formed by XG and GA in the simulated gastric fluid (pH 1.2). (C) 2004 Wiley Periodicals, Inc. |
| 英文摘要 | The use of floating drug-delivery systems is one method that is used to achieve prolonged gastric residence times. We developed a novel, multiple-unit, floating drug-delivery system of microspheres with microballoons inside from xanthan gum (XG) and gelatin (GA) by a water-in-oil method. With theophylline as the model drug, four formulations (FI-FIV) with different ratios of the two polymers were prepared. The size distribution, drug-encapsulation efficiency, floating behavior, release characteristics, and morphological properties were investigated. The ratio of the two polymers influenced the size distribution, encapsulation efficiency, and drug release appreciably. With increasing amounts of GA, the percentage yield of the floating microspheres and the drug-encapsulation efficiency decreased from 100 and 84.5% to 31 and 56.2%, respectively. The drug-release rate also decreased with increasing GA content, which was attributed to an increase in the crosslinking extent. An initial burst was observed, and after that, the drug was released slowly by a near-zero-order pattern, which was attributed to the low solubility of theophylline and the possible complexes formed by XG and GA in the simulated gastric fluid (pH 1.2). (C) 2004 Wiley Periodicals, Inc. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | GASTROINTESTINAL-TRACT ; RELEASE ; MICROCAPSULES ; THEOPHYLLINE ; PELLETS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000223459500024 |
| 公开日期 | 2013-11-05 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/4997]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, ZQ,Song, BZ,Li, QX,et al. Preparation of microspheres with microballoons inside for floating drug-delivery systems[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2004,94(1):197-202. |
| APA | Yang, ZQ,Song, BZ,Li, QX,Fan, HL,&Fan, OY.(2004).Preparation of microspheres with microballoons inside for floating drug-delivery systems.JOURNAL OF APPLIED POLYMER SCIENCE,94(1),197-202. |
| MLA | Yang, ZQ,et al."Preparation of microspheres with microballoons inside for floating drug-delivery systems".JOURNAL OF APPLIED POLYMER SCIENCE 94.1(2004):197-202. |
入库方式： OAI收割
来源：过程工程研究所
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