Modeling of the mixed culture and periodic control for PHB production
文献类型：期刊论文
| 作者 | Tohyama, M; Patarinska, T; Qiang, ZW; Shimizu, K |
| 刊名 | BIOCHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2002-04-01 |
| 卷号 | 10期号:3页码:157-173 |
| 关键词 | mixed culture PHB fermentation dynamics modeling periodic operation |
| ISSN号 | 1369-703X |
| 其他题名 | Biochem. Eng. J. |
| 中文摘要 | The unstructured mathematical model was developed in the present investigation for the mixed culture, where the metabolites produced by one microorganism is assimilated by the other microorganism. For this, we specifically employed such model system in which sugars such as glucose were converted to lactate by Lactobacillus delbrueckii and the lactate was converted in turn to poly-beta-hydroxybutyrate (PHB) by Ralstonia eutropha in one fermentor. Several batch and fed-batch culture experiments were conducted using each microorganism at different dissolved oxygen (DO) concentrations. Those experimental data were then fitted to the mathematical model, which can describe the dynamics of a mixed culture. Some of the model parameters were expressed as functions of DO concentrations, and some of the other model parameters were tuned based on the mixed culture experiments. The model developed describes the effects of such concentrations of glucose, lactate, DO, and NH3 on the dynamic behavior of such concentrations as both microorganisms, glucose, lactate, and PHB. Optimal operating condition was then investigated using the model developed, It was found that the periodic change in DO concentration improved such performance as PHB yield, and it was verified by experiments. The optimal NH3 concentration profile was also obtained for the efficient PHB production by the application of the maximum principle, (C) 2002 Elsevier Science B.V. All rights reserved. |
| 英文摘要 | The unstructured mathematical model was developed in the present investigation for the mixed culture, where the metabolites produced by one microorganism is assimilated by the other microorganism. For this, we specifically employed such model system in which sugars such as glucose were converted to lactate by Lactobacillus delbrueckii and the lactate was converted in turn to poly-beta-hydroxybutyrate (PHB) by Ralstonia eutropha in one fermentor. Several batch and fed-batch culture experiments were conducted using each microorganism at different dissolved oxygen (DO) concentrations. Those experimental data were then fitted to the mathematical model, which can describe the dynamics of a mixed culture. Some of the model parameters were expressed as functions of DO concentrations, and some of the other model parameters were tuned based on the mixed culture experiments. The model developed describes the effects of such concentrations of glucose, lactate, DO, and NH3 on the dynamic behavior of such concentrations as both microorganisms, glucose, lactate, and PHB. Optimal operating condition was then investigated using the model developed, It was found that the periodic change in DO concentration improved such performance as PHB yield, and it was verified by experiments. The optimal NH3 concentration profile was also obtained for the efficient PHB production by the application of the maximum principle, (C) 2002 Elsevier Science B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Engineering, Chemical |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Engineering |
| 关键词[WOS] | BETA-HYDROXYBUTYRIC ACID ; LACTOCOCCUS-LACTIS IO-1 ; ALCALIGENES-EUTROPHUS ; LACTOBACILLUS-DELBRUECKII ; POLY(BETA-HYDROXYBUTYRIC ACID) ; SACCHAROMYCES-CEREVISIAE ; FERMENTATIVE PRODUCTION ; MATHEMATICAL-MODEL ; RALSTONIA-EUTROPHA ; COCULTURE SYSTEM |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000175027100001 |
| 公开日期 | 2013-11-12 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5649]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Kyushu Inst Technol, Dept Biochem Engn, Fukuoka 8200067, Japan 2.Bulgarian Acad Sci, Inst Control & Syst Res, Dept Adapt & Robust Control, Sofia, Bulgaria 3.Chinese Acad Sci, Inst Chem Met, State Key Lab Biochem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tohyama, M,Patarinska, T,Qiang, ZW,et al. Modeling of the mixed culture and periodic control for PHB production[J]. BIOCHEMICAL ENGINEERING JOURNAL,2002,10(3):157-173. |
| APA | Tohyama, M,Patarinska, T,Qiang, ZW,&Shimizu, K.(2002).Modeling of the mixed culture and periodic control for PHB production.BIOCHEMICAL ENGINEERING JOURNAL,10(3),157-173. |
| MLA | Tohyama, M,et al."Modeling of the mixed culture and periodic control for PHB production".BIOCHEMICAL ENGINEERING JOURNAL 10.3(2002):157-173. |
入库方式： OAI收割
来源：过程工程研究所
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