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The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models

文献类型:期刊论文

作者Shi, Leming1; Campbell, Gregory2; Jones, Wendell D.3; Campagne, Fabien4; Wen, Zhining1; Walker, Stephen J.5; Su, Zhenqiang6; Chu, Tzu-Ming7; Goodsaid, Federico M.8; Pusztai, Lajos9
刊名NATURE BIOTECHNOLOGY
出版日期2010-08-01
卷号28期号:8页码:827-U109
ISSN号1087-0156
关键词GENE-EXPRESSION DATA CONTROL MAQC PROJECT MULTIPLE-MYELOMA BREAST-CANCER PUBLISHED MICROARRAY FOLLICULAR LYMPHOMA RISK-STRATIFICATION DNA MICROARRAYS CLASSIFICATION PERFORMANCE
通讯作者Shi, LM
英文摘要Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]GENE-EXPRESSION DATA ; CONTROL MAQC PROJECT ; MULTIPLE-MYELOMA ; BREAST-CANCER ; PUBLISHED MICROARRAY ; FOLLICULAR LYMPHOMA ; RISK-STRATIFICATION ; DNA MICROARRAYS ; CLASSIFICATION ; PERFORMANCE
收录类别SCI
语种英语
WOS记录号WOS:000280757500023
公开日期2013-11-15
版本出版稿
源URL[http://ir.ipe.ac.cn/handle/122111/6111]  
专题过程工程研究所_多相复杂系统国家重点实验室
作者单位1.US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA
2.US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA
3.Express Anal Inc, Durham, NC USA
4.Cornell Univ, Dept Physiol & Biophys, Weill Med Coll, New York, NY 10021 USA
5.Wake Forest Univ, Wake Forest Inst Regenerat Med, Winston Salem, NC 27109 USA
6.Z Tech, Jefferson, AR USA
7.SAS Inst Inc, Cary, NC USA
8.US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA
9.Univ Texas MD Anderson Canc Ctr, Breast Med Oncol Dept, Houston, TX 77030 USA
10.Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA
推荐引用方式
GB/T 7714
Shi, Leming,Campbell, Gregory,Jones, Wendell D.,et al. The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models[J]. NATURE BIOTECHNOLOGY,2010,28(8):827-U109.
APA Shi, Leming.,Campbell, Gregory.,Jones, Wendell D..,Campagne, Fabien.,Wen, Zhining.,...&MAQC Consortium.(2010).The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models.NATURE BIOTECHNOLOGY,28(8),827-U109.
MLA Shi, Leming,et al."The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models".NATURE BIOTECHNOLOGY 28.8(2010):827-U109.

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来源:过程工程研究所

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