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The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models
文献类型:期刊论文
作者 | Shi, Leming1; Campbell, Gregory2; Jones, Wendell D.3; Campagne, Fabien4; Wen, Zhining1; Walker, Stephen J.5; Su, Zhenqiang6; Chu, Tzu-Ming7; Goodsaid, Federico M.8; Pusztai, Lajos9 |
刊名 | NATURE BIOTECHNOLOGY |
出版日期 | 2010-08-01 |
卷号 | 28期号:8页码:827-U109 |
ISSN号 | 1087-0156 |
关键词 | GENE-EXPRESSION DATA CONTROL MAQC PROJECT MULTIPLE-MYELOMA BREAST-CANCER PUBLISHED MICROARRAY FOLLICULAR LYMPHOMA RISK-STRATIFICATION DNA MICROARRAYS CLASSIFICATION PERFORMANCE |
通讯作者 | Shi, LM |
英文摘要 | Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Biotechnology & Applied Microbiology |
研究领域[WOS] | Biotechnology & Applied Microbiology |
关键词[WOS] | GENE-EXPRESSION DATA ; CONTROL MAQC PROJECT ; MULTIPLE-MYELOMA ; BREAST-CANCER ; PUBLISHED MICROARRAY ; FOLLICULAR LYMPHOMA ; RISK-STRATIFICATION ; DNA MICROARRAYS ; CLASSIFICATION ; PERFORMANCE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000280757500023 |
公开日期 | 2013-11-15 |
版本 | 出版稿 |
源URL | [http://ir.ipe.ac.cn/handle/122111/6111] |
专题 | 过程工程研究所_多相复杂系统国家重点实验室 |
作者单位 | 1.US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA 2.US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA 3.Express Anal Inc, Durham, NC USA 4.Cornell Univ, Dept Physiol & Biophys, Weill Med Coll, New York, NY 10021 USA 5.Wake Forest Univ, Wake Forest Inst Regenerat Med, Winston Salem, NC 27109 USA 6.Z Tech, Jefferson, AR USA 7.SAS Inst Inc, Cary, NC USA 8.US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA 9.Univ Texas MD Anderson Canc Ctr, Breast Med Oncol Dept, Houston, TX 77030 USA 10.Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA |
推荐引用方式 GB/T 7714 | Shi, Leming,Campbell, Gregory,Jones, Wendell D.,et al. The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models[J]. NATURE BIOTECHNOLOGY,2010,28(8):827-U109. |
APA | Shi, Leming.,Campbell, Gregory.,Jones, Wendell D..,Campagne, Fabien.,Wen, Zhining.,...&MAQC Consortium.(2010).The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models.NATURE BIOTECHNOLOGY,28(8),827-U109. |
MLA | Shi, Leming,et al."The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models".NATURE BIOTECHNOLOGY 28.8(2010):827-U109. |
入库方式: OAI收割
来源:过程工程研究所
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