PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin
文献类型：期刊论文
| 作者 | Wang, Yin-Jue1,2; Hao, Su-Juan3; Liu, Yong-Dong1; Hu, Tao1; Zhang, Gui-Feng1; Zhang, Xuan4; Qi, Qing-Sheng5; Ma, Guang-Hui1; Su, Zhi-Guo1 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2010-08-03 |
| 卷号 | 145期号:3页码:306-313 |
| 关键词 | PEGylation Erythropoietin Non-glycosylated Pharmacokinetics In vivo activity |
| ISSN号 | 0168-3659 |
| 通讯作者 | Liu, YD |
| 英文摘要 | Recombinant human non-glycosylated erythropoietin (rh-ngEpo) expressed in E. coli was attached to polyethylene glycol (PEG) chains with different sizes and structures. The pharmacokinetic properties and in vivo potency of the PEGylated protein were investigated and comparisons were drawn between the conjugates and glycosylated recombinant Epo (rhEpo). |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | STRUCTURAL-CHARACTERIZATION ; BIOLOGICAL-ACTIVITY ; PROTEINS ; ANEMIA ; SURVIVAL ; SITE ; PHARMACOKINETICS ; CARBOHYDRATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280375600018 |
| 公开日期 | 2013-11-14 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5812]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Beijing 100029, Peoples R China 4.Tianjin Pegylatt Biotechnol Co Ltd, Tianjin 300457, Peoples R China 5.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yin-Jue,Hao, Su-Juan,Liu, Yong-Dong,et al. PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin[J]. JOURNAL OF CONTROLLED RELEASE,2010,145(3):306-313. |
| APA | Wang, Yin-Jue.,Hao, Su-Juan.,Liu, Yong-Dong.,Hu, Tao.,Zhang, Gui-Feng.,...&Su, Zhi-Guo.(2010).PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin.JOURNAL OF CONTROLLED RELEASE,145(3),306-313. |
| MLA | Wang, Yin-Jue,et al."PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin".JOURNAL OF CONTROLLED RELEASE 145.3(2010):306-313. |
入库方式： OAI收割
来源：过程工程研究所
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