Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats
文献类型：期刊论文
| 作者 | Ding, Zhongyang1,2,3; Lu, Yingjian1; Lu, Zhaoxin1; Lv, Fengxia1; Wang, Yuhong2,3; Bie, Xiaomei1; Wang, Feng4; Zhang, Kechang2,3 |
| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 121期号:1页码:39-43 |
| 关键词 | Coprinus comatus 4 Non-enzymatic glycosylation Hypoglycaemic Alloxan 5-Dihydroxy-2-methoxy-benzaldehyde |
| ISSN号 | 0308-8146 |
| 通讯作者 | Lu, ZX |
| 英文摘要 | Comatin, an inhibitor of the non-enzymatic glycosylation (NEG) reaction, was isolated from Coprinus comatus fermentation broth by macroporous resin separation, followed by chromatographic purification using a C18 reversed-phase column. The compound was identified as 4,5-dihydroxy-2-methoxy-benzal-dehyde by high-resolution MS, IR, NMR and UV analyses. The hypoglycaemic effect of comatin, on both normal and alloxan-induced-diabetic rats, was investigated in the paper. The blood glucose concentration of normal rats treated by the comatin at 80 mg/kg body weight was reduced from 5.14 mM to 4.28 mM in 3 h. Also, the concentrations of fructosamine, triglycerides and total cholesterol in induced-diabetic rats were significantly decreased. These results indicated that comatin could maintain a low level of blood glucose and improve glucose tolerance. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics |
| 研究领域[WOS] | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
| 关键词[WOS] | IN-VITRO ; FRUITING BODIES ; GLYCATION ; MELLITUS ; INHIBITION ; MUSHROOM ; PRODUCTS ; EXTRACTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275360200005 |
| 公开日期 | 2013-11-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6122]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Nanjing Agr Univ, Sch Food Sci & Technol, Nanjing 210095, Peoples R China 2.Jiangnam Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Peoples R China 3.Jiangnam Univ, Sch Biotechnol, Wuxi 214122, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Zhongyang,Lu, Yingjian,Lu, Zhaoxin,et al. Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats[J]. FOOD CHEMISTRY,2010,121(1):39-43. |
| APA | Ding, Zhongyang.,Lu, Yingjian.,Lu, Zhaoxin.,Lv, Fengxia.,Wang, Yuhong.,...&Zhang, Kechang.(2010).Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats.FOOD CHEMISTRY,121(1),39-43. |
| MLA | Ding, Zhongyang,et al."Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats".FOOD CHEMISTRY 121.1(2010):39-43. |
入库方式： OAI收割
来源：过程工程研究所
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