Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation
文献类型：期刊论文
| 作者 | Wei, Wei1,2; Yue, Zhan-Guo1,2; Qu, Jian-Bo3; Yue, Hua1,2; Su, Zhi-Guo1; Ma, Guang-Hui1 |
| 刊名 | NANOMEDICINE
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 5期号:4页码:589-596 |
| 关键词 | 10-hydroxycamptothecin anticancer asialoglycoprotein receptor drug delivery nanocrystallites |
| ISSN号 | 1743-5889 |
| 通讯作者 | Ma, GH |
| 英文摘要 | Aim: Low solubility in water has become an intrinsic property of many anticancer drugs, which poses a hurdle in the translation from the bench to the clinic. In this study, we developed a facile method to prepare 10-hydroxycamptothecin (HCPT) nanocrystallites and testified their feasibility for liver-targeting therapy. Materials & methods: HCPT nanocrystallites were prepared under the soft template effect of galactosylated chitosan. The internalization profile, intracellular trafficking, drug activity and cell viability were evaluated by exposing these nanocrystallites to human hepatocellular carcinoma HepG2 cells. Results: Galactosylated chitosan located on the HCPT nanocrystallites not only stabilized the formulation in aqueous medium, but also enhanced the cellular internalization through an asialoglycoprotein receptor-mediated pathway. These nanocrystallites also exhibited the advantages of nuclear entry and active HCPT delivery, and consequently better anticancer cytotoxicity could be achieved. Conclusion: These data strongly support the superior properties of galactosylated HCPT nanocrystallites on liver-targeting therapy. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 关键词[WOS] | NUCLEAR-LOCALIZATION SIGNAL ; WATER-SOLUBLE DRUGS ; PLASMID DNA ; CURRENT PERSPECTIVES ; CANCER-THERAPY ; DELIVERY ; CAMPTOTHECIN ; CHITOSAN ; CELLS ; PERMEABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278937100010 |
| 公开日期 | 2013-11-18 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6143]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.China Univ Petr, Ctr Bioengn & Biotechnol, Qingdao 266555, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Yue, Zhan-Guo,Qu, Jian-Bo,et al. Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation[J]. NANOMEDICINE,2010,5(4):589-596. |
| APA | Wei, Wei,Yue, Zhan-Guo,Qu, Jian-Bo,Yue, Hua,Su, Zhi-Guo,&Ma, Guang-Hui.(2010).Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation.NANOMEDICINE,5(4),589-596. |
| MLA | Wei, Wei,et al."Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation".NANOMEDICINE 5.4(2010):589-596. |
入库方式： OAI收割
来源：过程工程研究所
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