Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique
文献类型：期刊论文
| 作者 | Zhao, Qing Sheng1,2,3; Ji, Qiu Xia4; Cheng, Xiao Jie1; Sun, Gang Zheng1; Ran, Chao1; Zhao, Bing2; Chen, Xi Guang1 |
| 刊名 | JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 54期号:2页码:232-237 |
| ISSN号 | 0928-0707 |
| 关键词 | Chitosan Sodium alginate Hydrogel Beads Thermosensitive |
| 通讯作者 | Chen, XG |
| 英文摘要 | Chitosan hydrogel beads were successfully prepared by the method of thermosensitive internal gelation technique. The prepared beads were spherical, smooth-surfaced and non-aggregated with a diameter of 1.7-2.1 mm. The diameters of beads can be controlled and have a correlation with the initial drop size, the concentration of CaCl2, alginate and the time of solidification. The bead is comprised of three parts, which are chitosan/glycerophosphate (CS/GP) hydrogel core, chitosan-alginate (CS/SA) gel layer in the middle and calcium-alginate gelatin capsules in outer layer. Swelling studies indicate that the beads can be stable in simulated gastric fluid. But the beads shrink sharply when removed to simulated intestinal fluid. Drug release behavior showed that release of ornidazole in the beads is much slower than in the CS/GP hydrogel. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Ceramics |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | DRUG-DELIVERY SYSTEM ; BETA-GLYCEROPHOSPHATE ; IN-SITU ; CONTROLLED-RELEASE ; SODIUM-ALGINATE ; CELLS ; TEMPERATURE ; SCAFFOLDS ; MEMBRANE ; SURVIVAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277025200012 |
| 公开日期 | 2013-11-19 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6160]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Qingdao Univ, Coll Med, Affiliated Hosp, Qingdao 266001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qing Sheng,Ji, Qiu Xia,Cheng, Xiao Jie,et al. Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique[J]. JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY,2010,54(2):232-237. |
| APA | Zhao, Qing Sheng.,Ji, Qiu Xia.,Cheng, Xiao Jie.,Sun, Gang Zheng.,Ran, Chao.,...&Chen, Xi Guang.(2010).Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique.JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY,54(2),232-237. |
| MLA | Zhao, Qing Sheng,et al."Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique".JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY 54.2(2010):232-237. |
入库方式： OAI收割
来源：过程工程研究所
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