Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide
文献类型：期刊论文
| 作者 | Pan, XJ; Liu, HZ; An, ZT; Wang, J; Niu, GG |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2001-06-04 |
| 卷号 | 220期号:1-2页码:33-41 |
| 关键词 | penicillin G sulfoxide dehydration microwave enhanced washing FTIR spectroscopy |
| ISSN号 | 0378-5173 |
| 其他题名 | Int. J. Pharm. |
| 中文摘要 | In the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N-2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide. (C) 2001 Elsevier Science B.V. All rights reserved. |
| 英文摘要 | In the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N-2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide. (C) 2001 Elsevier Science B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000169184700004 |
| 公开日期 | 2013-11-14 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5763]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, State Key Lab Biochem Engn, Inst Chem Met, Young Sci Lab Separat Sci & Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, XJ,Liu, HZ,An, ZT,et al. Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2001,220(1-2):33-41. |
| APA | Pan, XJ,Liu, HZ,An, ZT,Wang, J,&Niu, GG.(2001).Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.INTERNATIONAL JOURNAL OF PHARMACEUTICS,220(1-2),33-41. |
| MLA | Pan, XJ,et al."Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide".INTERNATIONAL JOURNAL OF PHARMACEUTICS 220.1-2(2001):33-41. |
入库方式： OAI收割
来源：过程工程研究所
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