Design, synthesis and structure-activity relationships of novel ALS inhibitors
文献类型：期刊论文
| 作者 | Ren, TR; Yang, HW; Gao, X; Yang, XL; Zhou, JJ; Cheng, FH |
| 刊名 | PEST MANAGEMENT SCIENCE
 |
| 出版日期 | 2000-03-01 |
| 卷号 | 56期号:3页码:218-226 |
| 关键词 | molecular modelling Apex-3D herbicides ALS inhibitors |
| ISSN号 | 1526-498X |
| 其他题名 | Pest Manag. Sci. |
| 中文摘要 | The paper describes the biophore models of sulfonylurea, imidazolinone, triazolopyrimidinesulfonamide and 5-pyrimidyltriazolo-3-sulfonamides established by the Apex-3D method. A series of N-phenylsulfonyl-N'-(thiadiazol-2-yl) oxamides and three types of triazolopyrimidinesulfonamide were synthesised and their herbicidal activities determined to assess the validity of the model. In general, the model gave useful leads to activity, although the actual level was not always predicted accurately. In only a few cases did compounds predicted as being active prove to be inactive in the bioassay, and compounds with little or no activity were clearly indicated, As a result of this work, the compound N,N'-[1-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-ylthio)butane-2,3-di-imino]bis(2-chlorobenzenesulfonamide) was selected as showing good activity against a range of species, and will be used as a lead for further development, (C) 2000 Society of Chemical Industry. |
| 英文摘要 | The paper describes the biophore models of sulfonylurea, imidazolinone, triazolopyrimidinesulfonamide and 5-pyrimidyltriazolo-3-sulfonamides established by the Apex-3D method. A series of N-phenylsulfonyl-N'-(thiadiazol-2-yl) oxamides and three types of triazolopyrimidinesulfonamide were synthesised and their herbicidal activities determined to assess the validity of the model. In general, the model gave useful leads to activity, although the actual level was not always predicted accurately. In only a few cases did compounds predicted as being active prove to be inactive in the bioassay, and compounds with little or no activity were clearly indicated, As a result of this work, the compound N,N'-[1-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-ylthio)butane-2,3-di-imino]bis(2-chlorobenzenesulfonamide) was selected as showing good activity against a range of species, and will be used as a lead for further development, (C) 2000 Society of Chemical Industry. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Agronomy ; Entomology |
| 研究领域[WOS] | Agriculture ; Entomology |
| 关键词[WOS] | ACETOLACTATE SYNTHASE ; DERIVATIVES ; SITE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000086542000002 |
| 公开日期 | 2013-11-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5886]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem Met, Lab Comp Chem, Beijing 100080, Peoples R China 2.China Agr Univ, Dept Appl Chem, Beijing 100094, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, TR,Yang, HW,Gao, X,et al. Design, synthesis and structure-activity relationships of novel ALS inhibitors[J]. PEST MANAGEMENT SCIENCE,2000,56(3):218-226. |
| APA | Ren, TR,Yang, HW,Gao, X,Yang, XL,Zhou, JJ,&Cheng, FH.(2000).Design, synthesis and structure-activity relationships of novel ALS inhibitors.PEST MANAGEMENT SCIENCE,56(3),218-226. |
| MLA | Ren, TR,et al."Design, synthesis and structure-activity relationships of novel ALS inhibitors".PEST MANAGEMENT SCIENCE 56.3(2000):218-226. |
入库方式： OAI收割
来源：过程工程研究所
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