Kinetics of base catalyzed racemization of ibuprofen enantiomers
文献类型：期刊论文
| 作者 | Xie, YC; Liu, HZ; Chen, JY |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2000-02-25 |
| 卷号 | 196期号:1页码:21-26 |
| 关键词 | ibuprofen enantiomer resolution racemization kinetics base catalysis |
| ISSN号 | 0378-5173 |
| 其他题名 | Int. J. Pharm. |
| 中文摘要 | The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved. |
| 英文摘要 | The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | RACEMIC IBUPROFEN ; ESTERIFICATION ; SOLVENT ; LIPASE ; DRUGS ; ENOL |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000085614600003 |
| 公开日期 | 2013-11-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5975]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Kinetics of base catalyzed racemization of ibuprofen enantiomers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,196(1):21-26. |
| APA | Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of base catalyzed racemization of ibuprofen enantiomers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,196(1),21-26. |
| MLA | Xie, YC,et al."Kinetics of base catalyzed racemization of ibuprofen enantiomers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 196.1(2000):21-26. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。