Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane
文献类型：期刊论文
| 作者 | Xie, YC; Liu, HZ; Chen, JY |
| 刊名 | CHINESE JOURNAL OF CHEMICAL ENGINEERING
 |
| 出版日期 | 2000-03-01 |
| 卷号 | 8期号:1页码:6-14 |
| 关键词 | resolution kinetics lipase S-ibuprofen water content organic solvent dispersant |
| ISSN号 | 1004-9541 |
| 其他题名 | Chin. J. Chem. Eng. |
| 中文摘要 | The kinetics of Candida rugosa lipase catalyzed esterification of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Pi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esterification of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration. |
| 英文摘要 | The kinetics of Candida rugosa lipase catalyzed esterification of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Pi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esterification of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical |
| 研究领域[WOS] | Engineering |
| 关键词[WOS] | ORGANIC-SOLVENTS ; WATER ACTIVITY ; ESTER PRODRUG ; THERMOSTABILITY ; RESOLUTION ; ENZYMES ; DRUGS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000086195700002 |
| 公开日期 | 2013-11-15 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/5978]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Chem Met, Young Scientist Lab Separat Sci & Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2000,8(1):6-14. |
| APA | Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane.CHINESE JOURNAL OF CHEMICAL ENGINEERING,8(1),6-14. |
| MLA | Xie, YC,et al."Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane".CHINESE JOURNAL OF CHEMICAL ENGINEERING 8.1(2000):6-14. |
入库方式： OAI收割
来源：过程工程研究所
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