Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate
文献类型：期刊论文
| 作者 | Yang HX(杨会霞)1,2; Wang WB(王文波)1 ; Zhang JP(张俊平)1; Wang AQ(王爱勤)1; Wang AQ(王爱勤)
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| 刊名 | International Journal of Polymeric Materials and Polymeric Biomaterials
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| 出版日期 | 2013 |
| 卷号 | 62期号:7页码:369-376 |
| 关键词 | Attapulgite composite hydrogel bead drug-release behavior guar gum pH-sensitive |
| ISSN号 | 0091-4037 |
| 通讯作者 | 王爱勤 |
| 英文摘要 | A novel guar gum-g-poly (acrylic acid)/attapulgite/sodium alginate (GG-g-PAA/APT/SA) composite hydrogel bead with excellent pH sensitivity was prepared via a facile ionic gelation approach and characterized by FTIR and SEM techniques. The effect of APT content on the encapsulation efficiency (EE), swelling ratio, and drug release behaviors of the beads was investigated and the in-vitro release kinetics were also evaluated using diclofenac sodium (DS) as the model drug. The results indicate that the burst release effect of DS drug was eliminated due to the incorporation of APT, and the DS cumulative release was clearly decreased with increasing the APT content. |
| 学科主题 | 功能复合材料 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (No. 51003112);the Science and Technology Support Project of Jiangsu Provincial Science & Tech. Department (No. BY2010012) |
| 语种 | 英语 |
| WOS记录号 | WOS:000319171300001 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://210.77.64.217/handle/362003/4533]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 通讯作者 | Wang AQ(王爱勤) |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, R&D Ctr Xuyi Attapulgite Appl Technol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang HX,Wang WB,Zhang JP,et al. Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate[J]. International Journal of Polymeric Materials and Polymeric Biomaterials,2013,62(7):369-376. |
| APA | Yang HX,Wang WB,Zhang JP,Wang AQ,&王爱勤.(2013).Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate.International Journal of Polymeric Materials and Polymeric Biomaterials,62(7),369-376. |
| MLA | Yang HX,et al."Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate".International Journal of Polymeric Materials and Polymeric Biomaterials 62.7(2013):369-376. |
入库方式： OAI收割
来源：兰州化学物理研究所
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