Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line
文献类型：期刊论文
| 作者 | Lv, M（吕敏） ; Zhang, YJ ; Liang, L ; Wei, M（魏敏） ; Hu, WB ; Li, XM ; Huang, Q（黄庆） |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:13 |
| ISSN号 | 2040-3364 |
| 英文摘要 | Graphene oxide (GO), has created an unprecedented opportunity for development and application in biology, due to its abundant functional groups and well water solubility. Recently, the potential toxicity of GO in the environment and in humans has garnered more and more attention. In this paper, we systematically studied the cytotoxicity of GO nanosheets via examining the effect of GO on the morphology, viability and differentiation of a human neuroblastoma SH-SY5Y cell line, which was an ideal model used to study neuronal disease in vitro. The results suggested that GO had no obvious cytotoxicity at low concentration (<80 mu g mL(-1)) for 96 h, but the viability of cells exhibited dose-and time-dependent decreases at high concentration (>= 80 mu g mL(-1)). Moreover, GO did not induce apoptosis. Very interestingly, GO significantly enhanced the differentiation of SH-SY5Y induced-retinoic acid (RA) by evaluating neurite length and the expression of neuronal marker MAP2. These data provide a promising application for neurodegenerative diseases. |
| 语种 | 英语 |
| WOS记录号 | WOS:000305255600007 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13138]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lv, M,Zhang, YJ,Liang, L,et al. Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line[J]. NANOSCALE,2012,4(13). |
| APA | Lv, M.,Zhang, YJ.,Liang, L.,Wei, M.,Hu, WB.,...&Huang, Q.(2012).Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line.NANOSCALE,4(13). |
| MLA | Lv, M,et al."Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line".NANOSCALE 4.13(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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