Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors
文献类型：期刊论文
| 作者 | Gao, AR ; Lu, N（鲁娜） ; Wang, YC ; Dai, PF ; Li, T ; Gao, XL ; Wang, YL ; Fan, CH(樊春海） |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:10 |
| ISSN号 | 1530-6984 |
| 英文摘要 | Silicon nanowire (SiNW) field effect transistors (FETs) have emerged as powerful sensors for ultrasensitive, direct electrical readout, and label-free biological/chemical detection. The sensing mechanism of SiNW-FET can be understood in terms of the change in charge density at the SiNW surface after hybridization. So far, there have been limited systematic studies on fundamental factors related to device sensitivity to further make clear the overall effect on sensing sensitivity. Here, we present an analytical result for our triangle cross-section wire for predicting the sensitivity of nanowire surface-charge sensors. It was confirmed through sensing experiments that the back-gated SiNW-FET sensor had the highest percentage current response in the subthreshold regime and the sensor performance could be optimized in low buffer ionic strength and at moderate probe concentration. The optimized SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of target DNA with a detection limit of 0.1 fM and high specificity for single-nucleotide polymorphism discrimination. In our work, enhanced sensing of biological species by optimization of operating parameters and fundamental understanding for SiNW PET detection limit was obtained. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309615000032 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13151]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Gao, AR,Lu, N,Wang, YC,et al. Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors[J]. NANO LETTERS,2012,12(10). |
| APA | Gao, AR.,Lu, N.,Wang, YC.,Dai, PF.,Li, T.,...&Fan, CH.(2012).Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors.NANO LETTERS,12(10). |
| MLA | Gao, AR,et al."Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors".NANO LETTERS 12.10(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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