Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy
文献类型：期刊论文
| 作者 | Zhu, Y（诸颖） ; Li, WX（李文新） ; Zhang, Y ; Li, J ; Liang, L ; Zhang, XZ（张祥志） ; Chen, N ; Sun, YH ; Chen, W ; Tai, RZ（邰仁忠） ; Fan, CH（樊春海） ; Huang, Q（黄庆） |
| 刊名 | SMALL
 |
| 出版日期 | 2012 |
| 卷号 | 8期号:11 |
| ISSN号 | 1613-6810 |
| 英文摘要 | Nanodiamonds (NDs) possess many excellent physical and chemical properties that make them attractive materials for applications in biomedicine. In this paper, the adsorption and delivery of a large amount of sodium ions into the cell interior by NDs in serum-free medium is demonstrated. The excess sodium ions inside the cells induce osmotic stresses followed by cell swelling and an increase in the intracellular levels of calcium and reactive oxygen species (ROS), which leads to severe cellular damage. In complete culture medium, however, serum proteins wrapped around the NDs effectively prevent the sodium ions from adsorbing onto the NDs, and thus the NDs show no cytotoxicity. This work is the first to elaborate on the correlation between the sodium ions adsorbed on the nanomaterials and their bio-effects. Excessive ions delivered into cells by NDs might have potential applications in tumor therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000304817700018 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13157]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhu, Y,Li, WX,Zhang, Y,et al. Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy[J]. SMALL,2012,8(11). |
| APA | Zhu, Y.,Li, WX.,Zhang, Y.,Li, J.,Liang, L.,...&Huang, Q.(2012).Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy.SMALL,8(11). |
| MLA | Zhu, Y,et al."Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy".SMALL 8.11(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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