Fc-fusion proteins: new developments and future perspectives
文献类型：期刊论文
| 作者 | Czajkowsky, DM ; Hu, J（胡钧） ; Shao, ZF ; Pleass, RJ |
| 刊名 | EMBO MOLECULAR MEDICINE
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:10 |
| ISSN号 | 1757-4676 |
| 英文摘要 | Since the first description in 1989 of CD4-Fc-fusion antagonists that inhibit human immune deficiency virus entry into T cells, Fc-fusion proteins have been intensely investigated for their effectiveness to curb a range of pathologies, with several notable recent successes coming to market. These promising outcomes have stimulated the development of novel approaches to improve their efficacy and safety, while also broadening their clinical remit to other uses such as vaccines and intravenous immunoglobulin therapy. This increased attention has also led to non-clinical applications of Fc-fusions, such as affinity reagents in microarray devices. Here we discuss recent results and more generally applicable strategies to improve Fc-fusion proteins for each application, with particular attention to the newer, less charted areas. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309446200001 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13165]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Czajkowsky, DM,Hu, J,Shao, ZF,et al. Fc-fusion proteins: new developments and future perspectives[J]. EMBO MOLECULAR MEDICINE,2012,4(10). |
| APA | Czajkowsky, DM,Hu, J,Shao, ZF,&Pleass, RJ.(2012).Fc-fusion proteins: new developments and future perspectives.EMBO MOLECULAR MEDICINE,4(10). |
| MLA | Czajkowsky, DM,et al."Fc-fusion proteins: new developments and future perspectives".EMBO MOLECULAR MEDICINE 4.10(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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