Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease
文献类型：期刊论文
| 作者 | Wang, HJ ; Wang, M ; Wang, B ; Li, M ; Chen, HQ ; Yu, XH(余笑寒） ; Yang, K（杨舸） ; Chai, ZF ; Zhao, YL ; Feng, WY |
| 刊名 | METALLOMICS
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:10 |
| ISSN号 | 1756-5901 |
| 英文摘要 | The mechanism that triggers amyloid-beta (A beta) fibrillation and aggregation is still elusive. Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and A beta with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of A beta aggregation and toxicity. By using an immunogold labeling technique combined with synchrotron radiation X-ray fluorescence microprobe (SR-mu XRF) scanning analysis, the profiles of APP, A beta 42 and Cu, Zn in the brain of APP transgenic mouse with the development of the disease were characterized. This investigation provides visual, kinetic and spatial evidence of the correlation of APP and A beta-metals in AD brain sections. The visual evidence demonstrates the association of metals Cu and Zn with A beta 42 during plaque formation, which helps implicate the role of metal ion homeostasis in human AD pathology. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310123100012 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13190]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, HJ,Wang, M,Wang, B,et al. Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease[J]. METALLOMICS,2012,4(10). |
| APA | Wang, HJ.,Wang, M.,Wang, B.,Li, M.,Chen, HQ.,...&Feng, WY.(2012).Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease.METALLOMICS,4(10). |
| MLA | Wang, HJ,et al."Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease".METALLOMICS 4.10(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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