Molecular Mechanism of Surface-Assisted Epitaxial Self-Assembly of Amyloid-like Peptides
文献类型：期刊论文
| 作者 | Kang, SG ; Li, H（李海） ; Huynh, T ; Zhang, FC（张富春） ; Xia, Z ; Zhang, Y（张益） ; Zhou, RH |
| 刊名 | ACS NANO
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:10 |
| ISSN号 | 1936-0851 |
| 英文摘要 | A surprising "upright" fibrilar conformation (with a height of similar to 2.6 nm) was observed with in situ atomic force microscopy (AFM) for an amyloid-like peptide (NH2-VGGAVVAV-COHN2) on mica surface, which is very different from its "flat" conformation (with a much smaller height of similar to 0.9 nm) on the HOPG surface. Our all-atom molecular dynamics (MD) simulations reveal that it is the strong electrostatic interactions between the N-terminus of the peptide and the mica surface that result in an upright conformation and a highly ordered beta-stranded structure on mica, with a height of 2.5 +/- 0.1 nm, consistent with the AFM experiment. Similarly, our MD simulations show that the same peptides adopt a flat conformation on HOPG surfaces due to the favorable hydrophobic interactions with HOPG. Our simulations also indicate that epitaxial patterns found in mica are preferentially controlled by anisotropic binding sites commer surate with the inherent crystallographic unit cell of the basal substrate. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310096100092 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13218]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Kang, SG,Li, H,Huynh, T,et al. Molecular Mechanism of Surface-Assisted Epitaxial Self-Assembly of Amyloid-like Peptides[J]. ACS NANO,2012,6(10). |
| APA | Kang, SG.,Li, H.,Huynh, T.,Zhang, FC.,Xia, Z.,...&Zhou, RH.(2012).Molecular Mechanism of Surface-Assisted Epitaxial Self-Assembly of Amyloid-like Peptides.ACS NANO,6(10). |
| MLA | Kang, SG,et al."Molecular Mechanism of Surface-Assisted Epitaxial Self-Assembly of Amyloid-like Peptides".ACS NANO 6.10(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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