Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic
文献类型：期刊论文
| 作者 | Li, HX(李海霞) ; Liu, YC ; Tang, RZ(唐壑智) ; Zhang, P(张鹏) ; Fu, HY(付海英) ; Yao, SD(姚思德) ; Wang, WF(王文锋) |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 55期号:7 |
| ISSN号 | 1674-7291 |
| 英文摘要 | The reactions between gatifloxacin (GFX) and various one-electron oxidants, such as (OH)-O-center dot, N-3 (center dot), Br-2 (center dot-), and SO4 (center dot-), have been studied by pulse radiolysis techniques. The GFX radical anion formed in the reaction of GFX with e(aq) (-) could either be protonated or deprotonated, and the absorption of GFX radical anion was located at 390 nm. The transient species produced by the reaction of GFX with (OH)-O-center dot radical shows a broad band in the 380-600 nm region with a shoulder, while the oxidation by N-3 (center dot), SO4 (center dot-), and Br-2 (center dot-) results in an absorption band with lambda (max) = 370 nm. At neutral condition (pH 7), the rate constants of GFX reacting with (OH)-O-center dot, N-3 (center dot), Br-2 (center dot-), SO4 (center dot-) and e(aq) (-) are estimated to be 1.0 x 10(10), 3.1 x 10(9), 2.8 x 10(9), 3.0 x 10(9), and 1.8 x 10(10) dm(3) mol(-1) s(-1), respectively. From the pH dependence on the formation of electron adducts and on the rate constant of GFX with e(aq) (-), the pK(a) of GFX radical anion is estimated to be 5.5 and 9.3. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306070500023 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13266]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, HX,Liu, YC,Tang, RZ,et al. Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic[J]. SCIENCE CHINA-CHEMISTRY,2012,55(7). |
| APA | Li, HX.,Liu, YC.,Tang, RZ.,Zhang, P.,Fu, HY.,...&Wang, WF.(2012).Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic.SCIENCE CHINA-CHEMISTRY,55(7). |
| MLA | Li, HX,et al."Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic".SCIENCE CHINA-CHEMISTRY 55.7(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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