Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression
文献类型：期刊论文
| 作者 | Ma, YF ; Yu, JF(于俊峰) ; Wang, C ; Shen, H(沈华) ; Wu, H |
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2012 |
| 卷号 | 23期号:1 |
| ISSN号 | 1001-8042 |
| 英文摘要 | Integrin alpha(v)beta(3), a cell adhesion molecule, plays a key role in angiogenesis and tumor cell metastasis and is therefore an important target for new therapeutic and diagnostic strategies. Since ROD bind to alpha(v)beta(3) particularly, a lot of ROD containing peptides were radiolabeled and evaluated as imaging or therapeutic agents. In this study, a new Re-188-RGD peptide analog was synthesized and characterized. Within 30 min, the Re-188-H-E[c(RGDyK)](2) was obtained in radiochemical purity of better than 95%. The His-E[c(RGDyK)](2) had a good integrin-binding affinity (50% inhibitiory concentracer (IC50=46.5x10(-9) nm) and exhibited active accumulation (7.20 +/- 1.06) in S180 tumor. Because of relatively fast washout in blood and normal tissues, the target/non-target ratio was high. Further experiments to improve the tumor targeting efficacy and in vivo kinetic profiles are in progress towards developing it into a promising radio agent. |
| 语种 | 英语 |
| WOS记录号 | WOS:000303971000009 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13274]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Ma, YF,Yu, JF,Wang, C,et al. Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression[J]. NUCLEAR SCIENCE AND TECHNIQUES,2012,23(1). |
| APA | Ma, YF,Yu, JF,Wang, C,Shen, H,&Wu, H.(2012).Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression.NUCLEAR SCIENCE AND TECHNIQUES,23(1). |
| MLA | Ma, YF,et al."Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression".NUCLEAR SCIENCE AND TECHNIQUES 23.1(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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