Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis
文献类型：期刊论文
| 作者 | Su, S ; Wei, XP ; Zhong, YL ; Guo, YY ; Su, YY ; Huang, Q(黄庆) ; Lee, ST ; Fan, CH(樊春海) ; He, Y |
| 刊名 | ACS NANO
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:3 |
| ISSN号 | 1936-0851 |
| 英文摘要 | Nanomaterial-based molecular beacons (nanoMBs) have been extensively explored due to unique merits of nanostructures, including gold nanoparticle (AuNP)-, carbon nanotube (CNT)-, and graphene-based nanoMBs. Those nanoMBs are well-studied; however, they possess relatively poor salt stability or low specificity, limiting their wide applications. Here, we present a novel kind of multicolor silicon-based nanoMBs by using AuNP-decorated silicon nanowires as high-performance quenchers. Significantly, the nanoMBs feature robust stability In high-concentration (0.1 M) salt solution and wide-ranging temperature (10-80 degrees C), high quenching efficiency (>90%) for various fluorophores (e.g., FAM, Cy5, and ROX), and large surfaces for simultaneous assembly of different DNA strands. We further show that silicon-based nanoMBs are highly effective for sensitive and specific multidetection of DNA targets. The unprecedented advantages of silicon-based multicolor nanoMBs would bring new opportunities for challenging bioapplications, such as allele discrimination, early cancer diagnosis, and molecular engineering, etc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000301945900075 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13288]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Su, S,Wei, XP,Zhong, YL,et al. Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis[J]. ACS NANO,2012,6(3). |
| APA | Su, S.,Wei, XP.,Zhong, YL.,Guo, YY.,Su, YY.,...&He, Y.(2012).Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis.ACS NANO,6(3). |
| MLA | Su, S,et al."Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis".ACS NANO 6.3(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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