Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord
文献类型：期刊论文
| 作者 | Hu, JZ ; Wu, TD ; Zeng, L ; Liu, HQ（刘慧强） ; He, Y ; Du, GH（杜国浩） ; Lu, HB |
| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 57期号:5 |
| ISSN号 | 0031-9155 |
| 英文摘要 | Computed tomography combined with angiography has recently been developed to visualize three-dimensional (3D) vascular structure in experimental and clinical studies. However, there remain difficulties in using conventional x-ray angiography to detect small vessels with a diameter less than 200 mu m. This study attempted to develop a novel method for visualizing the micro-angioarchitecture of rat spinal cord. Herein, synchrotron radiation-based x-ray in-line phase contrast computed tomography (IL-XPCT) was used to obtain 3D micro-vessel structure without angiography. The digital phase contrast images were compared with conventional histological sections. Our results clearly demonstrated that the resolution limit of the spatial blood supply network in the normal rat thoracic cord appeared to be as small as similar to 10 mu m. The rendered images were consistent with that obtained from histomorphology sections. In summary, IL-XPCT is a potential tool to investigate the 3D neurovascular morphology of the rat spinal cord without the use of contrast agents, and it could help to evaluate the validity of the pro-or anti-angiogenesis therapeutic strategies on microvasculature repair or regeneration. |
| 语种 | 英语 |
| WOS记录号 | WOS:000300775600003 |
| 公开日期 | 2013-12-05 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13340]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Hu, JZ,Wu, TD,Zeng, L,et al. Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord[J]. PHYSICS IN MEDICINE AND BIOLOGY,2012,57(5). |
| APA | Hu, JZ.,Wu, TD.,Zeng, L.,Liu, HQ.,He, Y.,...&Lu, HB.(2012).Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord.PHYSICS IN MEDICINE AND BIOLOGY,57(5). |
| MLA | Hu, JZ,et al."Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord".PHYSICS IN MEDICINE AND BIOLOGY 57.5(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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