Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects
文献类型：期刊论文
| 作者 | Gayle E. Woloschak ; Christine A. Falaschetti,† Tatjana Paunesku,† Jasmina Kurepa,‡ Dhaval Nanavati,§ Stanley S. Chou,^ Mrinmoy De,^ MinHa Song, ) Jung-tak Jang, ) Aiguo Wu,z Vinayak P. Dravid,^ Jinwoo Cheon, ) Jan Smalle,‡ and Gayle E. Woloschak†,* |
| 刊名 | ACS NANO
 |
| 出版日期 | 2013-08-09 |
| 期号 | 9页码:7759—7772 |
| 通讯作者 | Gayle E. Woloschak |
| 合作状况 | 李雨桐 |
| 中文摘要 | The multicatalytic ubiquitin proteasome system (UPS) carries out proteolysis in a highly orchestrated way and regulates a large number of cellular processes. Deregulation of the UPS in many disorders has been documented. In some cases, such as carcinogenesis, elevated proteasome activity has been implicated in disease development, while the etiology of other diseases, such as neurodegeneration, includes decreased UPS activity. Therefore, agents that alter proteasome activity could suppress as well as enhance a multitude of diseases. Metal oxide nanoparticles, often developed as diagnostic tools, have not previously been tested as modulators of proteasome activity. Here, several types of metal oxide nanoparticles were found to adsorb to the proteasome and show variable preferential binding for particular proteasome subunits with several peptide binding “hotspots” possible. These interactions depend on the size, charge, and concentration of the nanoparticles and affect proteasome activity in a time-dependent manner. Should metal oxide nanoparticles increase proteasome activity in cells, as they do in vitro, unintended effects related to changes in proteasome function can be expected. |
| 学科主题 | 材料科学 |
| 原文出处 | SCI收录 |
| 公开日期 | 2013-12-16 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/10000]  |
| 专题 | 宁波材料技术与工程研究所_宁波所知识产出 |
| 推荐引用方式 GB/T 7714 | Gayle E. Woloschak,Christine A. Falaschetti,† Tatjana Paunesku,† Jasmina Kurepa,‡ Dhaval Nanavati,§ Stanley S. Chou,^ Mrinmoy De,^ MinHa Song, ) Jung-tak Jang, ) Aiguo Wu,z Vinayak P. Dravid,^ Jinwoo Cheon, ) Jan Smalle,‡ and Gayle E. Woloschak†,*. Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects[J]. ACS NANO,2013(9):7759—7772. |
| APA | Gayle E. Woloschak,&Christine A. Falaschetti,† Tatjana Paunesku,† Jasmina Kurepa,‡ Dhaval Nanavati,§ Stanley S. Chou,^ Mrinmoy De,^ MinHa Song, ) Jung-tak Jang, ) Aiguo Wu,z Vinayak P. Dravid,^ Jinwoo Cheon, ) Jan Smalle,‡ and Gayle E. Woloschak†,*.(2013).Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects.ACS NANO(9),7759—7772. |
| MLA | Gayle E. Woloschak,et al."Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects".ACS NANO .9(2013):7759—7772. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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