Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers
文献类型：期刊论文
| 作者 | Wu AG(吴爱国) ; Wenzhi Ren,a Leyong Zeng,a Zheyu Shen,a Lingchao Xiang,a An Gong,a Jichao Zhang,b Chengwen Mao,b Aiguo Li,b Tatjana Paunesku,c Gayle E. Woloschak,c Narayan S. Hosmaned and Aiguo Wu‡*a |
| 刊名 | RSC Advances
 |
| 出版日期 | 2013-08-21 |
| 期号 | 43页码:20855—20861 |
| 通讯作者 | 吴爱国 |
| 合作状况 | 李雨桐 |
| 中文摘要 | In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells. |
| 学科主题 | 材料科学 |
| 原文出处 | SCI收录 |
| 公开日期 | 2013-12-16 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/10010]  |
| 专题 | 宁波材料技术与工程研究所_宁波所知识产出 |
| 推荐引用方式 GB/T 7714 | Wu AG,Wenzhi Ren,a Leyong Zeng,a Zheyu Shen,a Lingchao Xiang,a An Gong,a Jichao Zhang,b Chengwen Mao,b Aiguo Li,b Tatjana Paunesku,c Gayle E. Woloschak,c Narayan S. Hosmaned and Aiguo Wu‡*a. Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers[J]. RSC Advances,2013(43):20855—20861. |
| APA | Wu AG,&Wenzhi Ren,a Leyong Zeng,a Zheyu Shen,a Lingchao Xiang,a An Gong,a Jichao Zhang,b Chengwen Mao,b Aiguo Li,b Tatjana Paunesku,c Gayle E. Woloschak,c Narayan S. Hosmaned and Aiguo Wu‡*a.(2013).Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers.RSC Advances(43),20855—20861. |
| MLA | Wu AG,et al."Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers".RSC Advances .43(2013):20855—20861. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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