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TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates

文献类型：期刊论文

作者Zhao Min1,2; Chen YanMing3; Qu DaCheng3; Qu Hong1; quh@mail.cbi.pku.edu.cn
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2011
卷号54期号:1页码:60-64
关键词Transporter Substrate Biological Database Compound Classification Compound Metabolic Network
ISSN号1674-7305
文献子类Article
英文摘要TSdb (http://tsdb.cbi.pku.edu.cn) is the first manually curated central repository that stores formatted information on the substrates of transporters. In total, 37608 transporters with 15075 substrates from 884 organisms were curated from UniProt functional annotation. A unique feature of TSdb is that all the substrates are mapped to identifiers from the KEGG Ligand compound database. Thus, TSdb links current metabolic pathway schema with compound transporter systems via the shared compounds in the pathways. Furthermore, all the transporter substrates in TSdb are classified according to their biochemical properties, biological roles and subcellular localizations. In addition to the functional annotation of transporters, extensive compound annotation that includes inhibitor information from the KEGG Ligand and BRENDA databases has been integrated, making TSdb a useful source for the discovery of potential inhibitory mechanisms linking transporter substrates and metabolic enzymes. User-friendly web interfaces are designed for easy access, query and download of the data. Text and BLAST searches against all transporters in the database are provided. We will regularly update the substrate data with evidence from new publications.
URL标识查看原文
WOS关键词RELATIONAL DATABASE ; RESOURCE ; KEGG ; PHARMACOGENOMICS ; INFORMATION ; UPDATE
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
WOS记录号WOS:000286470400009
公开日期2013-11-27
源URL[http://119.78.100.205/handle/311034/4482]  
专题古脊椎动物与古人类研究所_图书馆1
通讯作者quh@mail.cbi.pku.edu.cn
作者单位1.Peking Univ, Ctr Bioinformat, Natl Lab Prot Engn & Plant Genet Engn, Coll Life Sci, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Key Lab Evolutionary Systemat Vertebrates, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China
3.Beijing Inst Technol, Sch Comp Sci & Technol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714		 Zhao Min,Chen YanMing,Qu DaCheng,et al. TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(1):60-64.
APA Zhao Min,Chen YanMing,Qu DaCheng,Qu Hong,&quh@mail.cbi.pku.edu.cn.(2011).TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates.SCIENCE CHINA-LIFE SCIENCES,54(1),60-64.
MLA Zhao Min,et al."TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates".SCIENCE CHINA-LIFE SCIENCES 54.1(2011):60-64.

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来源：古脊椎动物与古人类研究所

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