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Dynamics of morphological changes for mitochondrial fission and fusion

文献类型：期刊论文

作者Wang ShiQi1,2,4; Fu ChangLiang1,2; Zhang Yan1,2; Chen Quan3; Long Mian1,2; mlong@imech.ac.cn
刊名SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
出版日期2010-04-01
卷号53期号:4页码:680-689
关键词Mitochondria Morphology Fission Fusion Dynamics Modeling
ISSN号1674-7348
文献子类Article
英文摘要Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.
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WOS关键词LIVING CELLS ; RETICULUM ; TRANSPORT
WOS研究方向Physics
语种英语
WOS记录号WOS:000276776100012
公开日期2013-11-27
源URL[http://119.78.100.205/handle/311034/4586]  
专题古脊椎动物与古人类研究所_图书馆1
古脊椎动物与古人类研究所_古哺乳动物研究室
通讯作者mlong@imech.ac.cn
作者单位1.Natl Micrograv Lab, Key Lab Micrograv, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714		 Wang ShiQi,Fu ChangLiang,Zhang Yan,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,2010,53(4):680-689.
APA Wang ShiQi,Fu ChangLiang,Zhang Yan,Chen Quan,Long Mian,&mlong@imech.ac.cn.(2010).Dynamics of morphological changes for mitochondrial fission and fusion.SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,53(4),680-689.
MLA Wang ShiQi,et al."Dynamics of morphological changes for mitochondrial fission and fusion".SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 53.4(2010):680-689.

入库方式： OAI收割

来源：古脊椎动物与古人类研究所

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